Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 423266..423825 | Replicon | chromosome |
| Accession | NZ_CP053745 | ||
| Organism | Vibrio cholerae strain SA3G | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D2YI11 |
| Locus tag | HPY04_RS15795 | Protein ID | WP_000578473.1 |
| Coordinates | 423266..423544 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | HPY04_RS15800 | Protein ID | WP_000381186.1 |
| Coordinates | 423541..423825 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY04_RS15760 | 418898..419395 | + | 498 | WP_175249432.1 | GNAT family N-acetyltransferase | - |
| HPY04_RS15765 | 419570..419806 | - | 237 | WP_000772125.1 | RNA-binding protein | - |
| HPY04_RS15770 | 420060..420494 | + | 435 | WP_095464275.1 | GNAT family N-acetyltransferase | - |
| HPY04_RS15775 | 420661..421128 | + | 468 | WP_175249433.1 | OsmC family protein | - |
| HPY04_RS15780 | 421429..421605 | + | 177 | WP_175249434.1 | DUF645 family protein | - |
| HPY04_RS15785 | 421958..422196 | + | 239 | Protein_423 | DUF645 family protein | - |
| HPY04_RS15790 | 422388..422576 | - | 189 | Protein_424 | helix-turn-helix domain-containing protein | - |
| HPY04_RS15795 | 423266..423544 | - | 279 | WP_000578473.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| HPY04_RS15800 | 423541..423825 | - | 285 | WP_000381186.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| HPY04_RS15805 | 424001..424192 | - | 192 | Protein_427 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY04_RS15810 | 424168..424239 | - | 72 | WP_146026931.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| HPY04_RS15815 | 424568..424993 | + | 426 | WP_071178894.1 | hypothetical protein | - |
| HPY04_RS15820 | 425194..425832 | + | 639 | WP_002051085.1 | HD domain-containing protein | - |
| HPY04_RS15825 | 425965..426435 | - | 471 | WP_175249435.1 | RES family NAD+ phosphorylase | - |
| HPY04_RS15830 | 426435..426887 | - | 453 | WP_000024294.1 | DUF2384 domain-containing protein | - |
| HPY04_RS15835 | 427101..427453 | + | 353 | Protein_433 | HAD-IA family hydrolase | - |
| HPY04_RS15840 | 427557..428561 | + | 1005 | WP_175249436.1 | LD-carboxypeptidase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 336942..428561 | 91619 | |
| - | inside | Integron | - | - | 388738..428561 | 39823 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10868.59 Da Isoelectric Point: 4.6794
>T157689 WP_000578473.1 NZ_CP053745:c423544-423266 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIETKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIETKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T157689 NZ_CP069447:c986886-986422 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGCGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAGCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGCGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAGCCATTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10915.28 Da Isoelectric Point: 8.0775
>AT157689 WP_000381186.1 NZ_CP053745:c423825-423541 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFVEHDIAKVR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFVEHDIAKVR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT157689 NZ_CP069447:c987221-986886 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCTGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCTGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|