Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 394855..395393 Replicon chromosome
Accession NZ_CP053745
Organism Vibrio cholerae strain SA3G

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag HPY04_RS15555 Protein ID WP_000802136.1
Coordinates 394855..395154 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag HPY04_RS15560 Protein ID WP_001107719.1
Coordinates 395151..395393 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY04_RS15505 390115..390294 + 180 WP_148508195.1 DUF645 family protein -
HPY04_RS15510 390492..390761 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
HPY04_RS15515 390754..391032 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
HPY04_RS15520 391227..391709 + 483 WP_095478190.1 GNAT family N-acetyltransferase -
HPY04_RS15525 391766..391949 + 184 Protein_371 acetyltransferase -
HPY04_RS15530 392054..392191 + 138 WP_175249663.1 DUF645 family protein -
HPY04_RS15535 392386..392868 + 483 WP_175249418.1 GNAT family N-acetyltransferase -
HPY04_RS15540 393009..393446 + 438 WP_057553402.1 NUDIX pyrophosphatase -
HPY04_RS15545 393753..393934 + 182 Protein_375 DUF645 family protein -
HPY04_RS15550 394141..394737 + 597 WP_175249419.1 methyltransferase domain-containing protein -
HPY04_RS15555 394855..395154 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY04_RS15560 395151..395393 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
HPY04_RS15565 396001..396471 + 471 WP_175249664.1 GNAT family N-acetyltransferase -
HPY04_RS15570 396615..397112 + 498 WP_033933253.1 GNAT family N-acetyltransferase -
HPY04_RS15575 397409..397495 + 87 WP_134820423.1 DUF645 family protein -
HPY04_RS15580 397498..397587 + 90 Protein_382 DUF645 family protein -
HPY04_RS15585 397876..398301 + 426 WP_071171304.1 hypothetical protein -
HPY04_RS15590 398571..398897 + 327 WP_175249420.1 hypothetical protein -
HPY04_RS15595 399112..399357 - 246 WP_175249421.1 hypothetical protein -
HPY04_RS15600 399916..400263 + 348 WP_001071511.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 336942..428561 91619
- inside Integron - - 388738..428561 39823


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T157685 WP_000802136.1 NZ_CP053745:c395154-394855 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T157685 NZ_CP069446:c20016-19735 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT157685 WP_001107719.1 NZ_CP053745:c395393-395151 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT157685 NZ_CP069446:c20257-20006 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
PDB 7R5A
PDB 7B22
AlphaFold DB A0A151JFU4

References