Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 390492..391032 Replicon chromosome
Accession NZ_CP053745
Organism Vibrio cholerae strain SA3G

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag HPY04_RS15510 Protein ID WP_000277238.1
Coordinates 390492..390761 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag HPY04_RS15515 Protein ID WP_001258569.1
Coordinates 390754..391032 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY04_RS15475 385712..387373 - 1662 WP_057552358.1 recombinase family protein -
HPY04_RS15480 387423..387920 - 498 WP_057552357.1 hypothetical protein -
HPY04_RS15485 388033..388440 - 408 WP_057552356.1 PH domain-containing protein -
HPY04_RS15490 388453..388620 - 168 WP_154590131.1 hypothetical protein -
HPY04_RS15495 388738..389202 + 465 WP_032473198.1 ASCH domain-containing protein -
HPY04_RS15500 389347..389835 + 489 WP_142626769.1 hypothetical protein -
HPY04_RS15505 390115..390294 + 180 WP_148508195.1 DUF645 family protein -
HPY04_RS15510 390492..390761 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
HPY04_RS15515 390754..391032 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HPY04_RS15520 391227..391709 + 483 WP_095478190.1 GNAT family N-acetyltransferase -
HPY04_RS15525 391766..391949 + 184 Protein_371 acetyltransferase -
HPY04_RS15530 392054..392191 + 138 WP_175249663.1 DUF645 family protein -
HPY04_RS15535 392386..392868 + 483 WP_175249418.1 GNAT family N-acetyltransferase -
HPY04_RS15540 393009..393446 + 438 WP_057553402.1 NUDIX pyrophosphatase -
HPY04_RS15545 393753..393934 + 182 Protein_375 DUF645 family protein -
HPY04_RS15550 394141..394737 + 597 WP_175249419.1 methyltransferase domain-containing protein -
HPY04_RS15555 394855..395154 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY04_RS15560 395151..395393 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 336942..428561 91619
- inside Integron - - 388738..428561 39823


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T157684 WP_000277238.1 NZ_CP053745:c390761-390492 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T157684 NZ_CP069445:c4887475-4887257 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT157684 WP_001258569.1 NZ_CP053745:c391032-390754 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT157684 NZ_CP069445:c4887875-4887501 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References