Detailed information of TA system TA157683

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-Phd
• Location: 365528..366106
• Replicon: chromosome
• Accession: NZ_CP053745
• Organism: Vibrio cholerae strain SA3G

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HPY04_RS15325
• Protein ID: WP_001913968.1
• Coordinates: 365528..365845 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q7DCR7
• Locus tag: HPY04_RS15330
• Protein ID: WP_000557292.1
• Coordinates: 365864..366106 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY04_RS15280	360866..360967	+	102	WP_175249398.1	acetyltransferase	-
HPY04_RS15285	360957..361334	+	378	WP_175249399.1	VOC family protein	-
HPY04_RS15290	361628..361756	+	129	WP_088129246.1	DUF645 family protein	-
HPY04_RS15295	361772..361810	+	39	WP_108244118.1	hypothetical protein	-
HPY04_RS15300	361989..362798	+	810	WP_175249400.1	hypothetical protein	-
HPY04_RS15305	362717..362905	+	189	WP_175249401.1	DUF3265 domain-containing protein	-
HPY04_RS15310	362949..363629	+	681	WP_175249402.1	hypothetical protein	-
HPY04_RS15315	363848..364870	+	1023	WP_175249403.1	hypothetical protein	-
HPY04_RS15320	364911..365393	+	483	WP_001900268.1	hypothetical protein	-
HPY04_RS15325	365528..365845	-	318	WP_001913968.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY04_RS15330	365864..366106	-	243	WP_000557292.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY04_RS15335	366321..366836	+	516	WP_000090012.1	hypothetical protein	-
HPY04_RS15340	366992..367386	+	395	Protein_334	DUF3465 domain-containing protein	-
HPY04_RS15345	367532..368191	+	660	WP_071179796.1	hypothetical protein	-
HPY04_RS15350	368350..368673	+	324	WP_175249404.1	hypothetical protein	-
HPY04_RS15355	368889..369482	-	594	WP_057552378.1	hypothetical protein	-
HPY04_RS15360	369498..370403	-	906	WP_175249405.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	336942..428561	91619
	-	inside	Integron	-	-	338106..368673	30567

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12159.96 Da
• Isoelectric Point: 9.5425

>T157683 WP_001913968.1 NZ_CP053745:c365845-365528 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAD
FILIVAVLGQSQLPQKHLKQSRFVS

Nucleotide

• Length: 318 bp

>T157683 NZ_CP069445:4673013-4673411 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.25 Da
• Isoelectric Point: 5.6630

>AT157683 WP_000557292.1 NZ_CP053745:c366106-365864 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Nucleotide

• Length: 243 bp

>AT157683 NZ_CP069445:4672717-4673010 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAACTGGTTAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Antitoxin

• AlphaFold DB: Q7DCR7