Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2241892..2243717 Replicon chromosome
Accession NZ_CP053744
Organism Vibrio cholerae strain SA3G

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HPY04_RS10065 Protein ID WP_175249063.1
Coordinates 2241892..2243253 (+) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HPY04_RS10070 Protein ID WP_175249064.1
Coordinates 2243250..2243717 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY04_RS10040 2237482..2237820 + 339 WP_148505519.1 transcriptional regulator -
HPY04_RS10045 2237900..2238106 - 207 Protein_1946 hypothetical protein -
HPY04_RS10050 2238437..2239216 + 780 WP_148505516.1 metallophosphoesterase -
HPY04_RS10055 2239430..2240479 + 1050 WP_148505517.1 hypothetical protein -
HPY04_RS10060 2240454..2241299 + 846 WP_095472174.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
HPY04_RS10065 2241892..2243253 + 1362 WP_175249063.1 type II toxin-antitoxin system HipA family toxin Toxin
HPY04_RS10070 2243250..2243717 + 468 WP_175249064.1 helix-turn-helix domain-containing protein Antitoxin
HPY04_RS10075 2243975..2246305 - 2331 WP_175249065.1 DUF2357 domain-containing protein -
HPY04_RS10080 2246332..2248245 - 1914 WP_102786467.1 DUF3578 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-384)

Antitoxin

Cro/C1-type helix-turn-helix domain

(80-138)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51280.17 Da        Isoelectric Point: 4.8511

>T157681 WP_175249063.1 NZ_CP053744:2241892-2243253 [Vibrio cholerae]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFFFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
AGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNQDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPAGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEVLIKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Download         Length: 1362 bp

>T157681 NZ_CP069445:c4359708-4359556 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 16949.42 Da        Isoelectric Point: 10.9400

>AT157681 WP_175249064.1 NZ_CP053744:2243250-2243717 [Vibrio cholerae]
MKPSNKESVQATVARLRANRNQQQSKVGKNATHSSKEQTPLDTPTRSKASKNAKAVSAAGRKTEANKIIKHLLLGELTQG
QALKSLRINILGLRQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDALKSLLMDGEDG

Download         Length: 468 bp

>AT157681 NZ_CP069445:4359757-4359814 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References