Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4782196..4783028 Replicon chromosome
Accession NZ_CP053731
Organism Escherichia coli strain CP55_Sichuan

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1L4HFA4
Locus tag HP431_RS22940 Protein ID WP_032163901.1
Coordinates 4782196..4782570 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag HP431_RS22945 Protein ID WP_001295723.1
Coordinates 4782660..4783028 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP431_RS22900 4777592..4778758 + 1167 WP_042031746.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
HP431_RS22905 4778877..4779350 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
HP431_RS22910 4779548..4780606 + 1059 WP_001200891.1 FUSC family protein -
HP431_RS22915 4780778..4781107 + 330 WP_000450409.1 DUF496 family protein -
HP431_RS22920 4781208..4781390 - 183 WP_001016348.1 hypothetical protein -
HP431_RS22925 4781462..4781590 + 129 Protein_4475 transposase domain-containing protein -
HP431_RS22930 4781879..4781992 - 114 WP_001161660.1 DUF957 domain-containing protein -
HP431_RS22935 4782005..4782199 - 195 WP_000988600.1 hypothetical protein -
HP431_RS22940 4782196..4782570 - 375 WP_032163901.1 TA system toxin CbtA family protein Toxin
HP431_RS22945 4782660..4783028 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HP431_RS22950 4783191..4783412 - 222 WP_000692345.1 DUF987 domain-containing protein -
HP431_RS22955 4783475..4783951 - 477 WP_001186710.1 RadC family protein -
HP431_RS22960 4783963..4784442 - 480 WP_000860065.1 antirestriction protein -
HP431_RS22965 4784524..4785342 - 819 WP_001234631.1 DUF945 domain-containing protein -
HP431_RS22970 4785442..4785675 - 234 WP_113449103.1 DUF905 family protein -
HP431_RS22975 4785754..4786209 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13919.89 Da        Isoelectric Point: 7.7760

>T157640 WP_032163901.1 NZ_CP053731:c4782570-4782196 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T157640 NZ_CP069439:c131658-131500 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT157640 WP_001295723.1 NZ_CP053731:c4783028-4782660 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT157640 NZ_CP069439:c131926-131702 [Escherichia coli]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L4HFA4

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References