Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3692721..3693519 Replicon chromosome
Accession NZ_CP053731
Organism Escherichia coli strain CP55_Sichuan

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0P7PH46
Locus tag HP431_RS17695 Protein ID WP_000854896.1
Coordinates 3692721..3693098 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A234XUW5
Locus tag HP431_RS17700 Protein ID WP_024175300.1
Coordinates 3693145..3693519 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP431_RS17660 3688288..3689466 + 1179 WP_000094989.1 type II secretion system protein GspL -
HP431_RS17665 3689468..3690004 + 537 WP_000942795.1 GspM family type II secretion system protein YghD -
HP431_RS17670 3690418..3690744 - 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
HP431_RS17675 3690741..3691004 - 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
HP431_RS17680 3691076..3691942 - 867 WP_000014510.1 DUF4942 domain-containing protein -
HP431_RS17685 3692027..3692224 - 198 WP_000839255.1 DUF957 domain-containing protein -
HP431_RS17690 3692236..3692724 - 489 WP_000761662.1 hypothetical protein -
HP431_RS17695 3692721..3693098 - 378 WP_000854896.1 TA system toxin CbtA family protein Toxin
HP431_RS17700 3693145..3693519 - 375 WP_024175300.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HP431_RS17705 3693682..3693903 - 222 WP_000692358.1 DUF987 domain-containing protein -
HP431_RS17710 3693966..3694442 - 477 WP_001186727.1 RadC family protein -
HP431_RS17715 3694458..3694943 - 486 WP_000214386.1 antirestriction protein -
HP431_RS17720 3695033..3695851 - 819 WP_033884686.1 DUF945 domain-containing protein -
HP431_RS17725 3695942..3696175 - 234 WP_001117568.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3690741..3739154 48413


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14210.19 Da        Isoelectric Point: 7.2920

>T157635 WP_000854896.1 NZ_CP053731:c3693098-3692721 [Escherichia coli]
MKTLSDTHVREASRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRMVNNITQGKHPEAQQ

Download         Length: 378 bp

>T157635 NZ_CP069438:c3800804-3800652 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13664.42 Da        Isoelectric Point: 6.4757

>AT157635 WP_024175300.1 NZ_CP053731:c3693519-3693145 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVKPCFGARLVQEGNRLHYLADRAGISGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHSVTLYAKGLTCEADTLGSCGYVYLTVYPTPATATTS

Download         Length: 375 bp

>AT157635 NZ_CP069438:3800853-3800910 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P7PH46

Antitoxin

Source ID Structure
AlphaFold DB A0A234XUW5

References