Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2346782..2347617 Replicon chromosome
Accession NZ_CP053731
Organism Escherichia coli strain CP55_Sichuan

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HP431_RS11330 Protein ID WP_064237107.1
Coordinates 2347240..2347617 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HP431_RS11325 Protein ID WP_057109690.1
Coordinates 2346782..2347150 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP431_RS11290 2343068..2343523 + 456 WP_000581504.1 hypothetical protein -
HP431_RS11295 2343602..2343835 + 234 WP_113449103.1 DUF905 family protein -
HP431_RS11300 2343935..2344753 + 819 WP_001234620.1 DUF945 domain-containing protein -
HP431_RS11305 2344808..2345293 + 486 WP_044860884.1 antirestriction protein -
HP431_RS11310 2345309..2345785 + 477 WP_001186726.1 RadC family protein -
HP431_RS11315 2345848..2346069 + 222 WP_000692315.1 DUF987 domain-containing protein -
HP431_RS11320 2346088..2346732 + 645 WP_113440689.1 antitoxin of toxin-antitoxin stability system -
HP431_RS11325 2346782..2347150 + 369 WP_057109690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HP431_RS11330 2347240..2347617 + 378 WP_064237107.1 type IV toxin-antitoxin system toxin CbtA Toxin
HP431_RS11335 2347614..2348102 + 489 WP_000761674.1 hypothetical protein -
HP431_RS11340 2348114..2348311 + 198 WP_000839236.1 DUF957 domain-containing protein -
HP431_RS11345 2348396..2349244 + 849 WP_086257745.1 DUF4942 domain-containing protein -
HP431_RS11350 2349303..2349506 - 204 WP_016234185.1 hypothetical protein -
HP431_RS11355 2349516..2350166 - 651 WP_000056760.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
HP431_RS11360 2350180..2350644 - 465 WP_000776520.1 PTS ascorbate transporter subunit IIA -
HP431_RS11365 2350654..2350959 - 306 WP_000218362.1 PTS ascorbate transporter subunit IIB -
HP431_RS11370 2350975..2352372 - 1398 WP_001296880.1 PTS ascorbate transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14091.12 Da        Isoelectric Point: 7.8840

>T157631 WP_064237107.1 NZ_CP053731:2347240-2347617 [Escherichia coli]
MKTLPVLPGQSASSRPSPVEIWQILLARLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNDITQGKHLETKR

Download         Length: 378 bp

>T157631 NZ_CP069438:c3419871-3419494 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACCCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAACTACAGAACGGTAAATGACATTACCCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13824.55 Da        Isoelectric Point: 6.4776

>AT157631 WP_057109690.1 NZ_CP053731:2346782-2347150 [Escherichia coli]
VSDSRHETNYPDDHNNRIWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGQFSDADAYHLEQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT157631 NZ_CP069438:c3420329-3419961 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACTCATCCCGACGACAATCGCGGCCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCACGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGATACCCTCGGCAGCTG
TGGTTGCGTTTATCTGGCTGTTTATCCGACACCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References