Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE(toxin)
Location 15747..16141 Replicon plasmid pCP61-IncFIB
Accession NZ_CP053729
Organism Escherichia coli strain CP61_Sichuan

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag HP432_RS00555 Protein ID WP_063120626.1
Coordinates 15747..16001 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag HP432_RS00560 Protein ID WP_172615625.1
Coordinates 15998..16141 (-) Length 48 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP432_RS00525 11729..12433 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
HP432_RS00530 12863..13003 + 141 WP_160784086.1 hypothetical protein -
HP432_RS00535 13076..13249 + 174 WP_172615624.1 hypothetical protein -
HP432_RS00540 13286..13990 + 705 WP_001067858.1 IS6-like element IS26 family transposase -
HP432_RS00545 14045..14356 - 312 Protein_18 IS6-like element IS26 family transposase -
HP432_RS00550 14424..15722 + 1299 Protein_19 Tn3-like element Tn3 family transposase -
HP432_RS00555 15747..16001 - 255 WP_063120626.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HP432_RS00560 15998..16141 - 144 WP_172615625.1 toxin-antitoxin system protein Antitoxin
HP432_RS00565 16181..16885 - 705 WP_001067858.1 IS6-like element IS26 family transposase -
HP432_RS00570 17035..17895 + 861 WP_000027057.1 class A broad-spectrum beta-lactamase TEM-1 -
HP432_RS00575 18039..19190 - 1152 Protein_24 multicopper oxidase PcoA -
HP432_RS00580 19425..19874 + 450 WP_001023231.1 hypothetical protein -
HP432_RS00585 20149..20886 + 738 WP_000287499.1 peptidoglycan DD-metalloendopeptidase family protein -
HP432_RS00590 20920..21117 - 198 WP_000843496.1 DUF2933 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid dfrA12 / aadA2 / cmlA1 / ant(3'')-Ia / sul3 / mef(B) / blaTEM-1B / mcr-3.1 / aac(3)-VIa / floR / tet(M) htpB 1..92076 92076
- inside IScluster/Tn dfrA12 / aadA2 / cmlA1 / ant(3'')-Ia / sul3 / mef(B) / blaTEM-1B - 1715..17895 16180


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9686.17 Da        Isoelectric Point: 6.4638

>T157589 WP_063120626.1 NZ_CP053729:c16001-15747 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMVAIELDERIGYSASSLAGQPYKGRNGRVEGARELVIHPHFVLVYEVDSPWGKV
YIGV

Download         Length: 255 bp

>T157589 NZ_CP069386:1390701-1391774 [Escherichia coli]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin


Download         Length: 48 a.a.        Molecular weight: 5430.16 Da        Isoelectric Point: 8.0286

>AT157589 WP_172615625.1 NZ_CP053729:c16141-15998 [Escherichia coli]
MQQCPWFRDQVAAGRQQLKRGDVLPHDMVESSAAAWRDEMSRKVADK

Download         Length: 144 bp

>AT157589 NZ_CP069386:1391767-1392138 [Escherichia coli]
TTGTTTGAAATCACCGGAATTAACGTCTCAGGGGCTCTAAAAGCTGTCGTTATGGCGACCGGCTTCGAGAACCCTTTGTC
CTCAGTTAATGAAATTGAGACGAAACTTTCTGCCCTACTGGGTAGTGAGACCACTGGTGAAATCCTTTTTGACCTCTTGT
GCGCTAACGGTCCAGAGTGGAACCGCTTCGTTACGCTGGAAATGAAATATGGCCGGATCATGCTGGATACGGCCAAAATT
ATTGATGAGCAGGACGTTCCGACACATATCCTGAGCAAACTGACTTTTACTTTACGTAATCATCCTGAGTACCTAGAAGC
CTCTGTTTTGTCTCCCGATGATGTACGCCAAGTCCTGTCAATGGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References