Detailed information of TA system TA157551

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 746906..747747
• Replicon: chromosome
• Accession: NZ_CP053723
• Organism: Escherichia coli strain CP66-6_Sichuan

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A1M0WJM1
• Locus tag: HP433_RS03535
• Protein ID: WP_000854822.1
• Coordinates: 747364..747747 (+)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: B7MK11
• Locus tag: HP433_RS03530
• Protein ID: WP_001285610.1
• Coordinates: 746906..747274 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HP433_RS03510	744650..745468	+	819	WP_001234702.1	DUF945 domain-containing protein	-
HP433_RS03515	745559..746044	+	486	WP_072794436.1	antirestriction protein	-
HP433_RS03520	746060..746536	+	477	WP_072661507.1	RadC family protein	-
HP433_RS03525	746605..746826	+	222	WP_000692350.1	DUF987 domain-containing protein	-
HP433_RS03530	746906..747274	+	369	WP_001285610.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HP433_RS03535	747364..747747	+	384	WP_000854822.1	type IV toxin-antitoxin system toxin CbtA	Toxin
HP433_RS03540	747738..748226	+	489	WP_001177592.1	hypothetical protein	-
HP433_RS03545	748238..748435	+	198	WP_000839263.1	DUF957 domain-containing protein	-
HP433_RS03550	748532..749377	+	846	WP_001280435.1	DUF4942 domain-containing protein	-
HP433_RS03560	749676..750182	+	507	WP_000228937.1	G/U mismatch-specific DNA glycosylase	-
HP433_RS03565	750260..752101	-	1842	WP_000437371.1	RNA polymerase sigma factor RpoD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14295.32 Da
• Isoelectric Point: 8.2830

>T157551 WP_000854822.1 NZ_CP053723:747364-747747 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHQESKRCN

Nucleotide

• Length: 384 bp

>T157551 NZ_CP069352:5672633-5673277 [Pseudomonas granadensis]
ATGAACTACACCAGCCTGAATCCAGAGAAGGCTCTGATTTGGCGTATCGTCCATCGCGATAACCTGCCCTGGATTCTGGA
CAACGGTCTGCATTGCGCGAACTCGGAAGTACAGGCACCTCAGTACGTGAACATAGGCAACGTCGACTTGATCGACAAAC
GCCGCTCGCGTCAGGTGCCTATTGCACCCGAAGGCGTTTTGGCCGACTACGTGCCCTTCTACTTCACGCCCTTCTCGGTA
ATGATGCAGAACATTCATTCTGGCTGGAGCGTTCAGCAGCGCACCAACGACGAGATCATCATTCTCGTTTCCAGCCTTTA
TCGCGTTGTCGAGCTGGGGCTACCGTTTGTCTTCACAAACGCACATGCCTACCCAGATTGGACAGACTATTACCGCGACC
TGACAAATCTCGACCAGATCGATTGGTCTATCCTTCAACGGCGCGACTTCAAGCGCGATCCTGATGACCCTCGCAAAATG
GAGCGTTATCAGGCTGAGGCGCTGATCCACCACCACTTACCGATTACGGGACTACTGGGCATCATGTGCCACACCGATGC
AATGAAAGTACGCATAGAAGCAGACGTTGAAGCTAGAGGCCTAACGTTGCCAGTCCATGCGCGCCCCAAATGGTATTTCC
AATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13606.39 Da
• Isoelectric Point: 6.0618

>AT157551 WP_001285610.1 NZ_CP053723:746906-747274 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT157551 NZ_CP069352:5673274-5674359 [Pseudomonas granadensis]
ATGATCAGATTCACCCAAGGCAACCTGCTGGAAGCCAAGACCGAAGCCCTCGTCAACACGGTGAATACCGTTGGCGTCAT
GGGTAAGGGCATCGCGCTGATGTTCAAAGAGCGCTTTGCGCAGAATTACCGCGTATATGCAGCGGCGTGTAAGGCCGGGA
AAGTAGAAACCGGCAAGATGCATGTGACTGCCACCGACGAACTCGATGGCCCTCGCTGGATTGTGAATTTTCCTACCAAG
CGCCACTGGCGGTCGCCGTCGCAAATGGCATGGATAACCGAAGGCTTGCATGATCTGCGGCGGTTCCTGCTTGAAAACGA
TGTGAAATCCGTCGCGATTCCACCGTTGGGTGCTGGCAATGGCGGCTTGAAGTGGCCCGAAGTCCGTGAGCAGATTGTCG
ACGTGTTGGGGGACCTGGATGCTGATGTATTGGTATTCGAGCCGTCCAATCAGTATCTGAATGTCGCCAAGCGTACAGGT
GTAGAAAAACTCACGCCTGCCCGCGCTCTTATCGCCGAACTGGTTCGTCGTTATTGGGTTTTAGGCATGGAGTGCAGTCT
GCTGGAAATCCAGAAGCTGGCCTGGTTTCTTGAGCGCGCAATTGAGCAGTTGCCGGATACAGAGAACCCTCTAAATCTAA
AATTTGTCGCGCACAAATATGGCCCATACGCCAACCGGCTGGAGCATCTGCTCGATAACCTCGATGGCAGTTATCTTCAC
TGTGACAAGCGCATCAGTGATGCAGGCATTAGTGATGTGATCTGGTTTGATCAAGAGCGCAAAGCGTTCTTGCAGACGTA
TCTGAAGACTGAGGCGAAGGACTATTCGCAAGCATTGGAGCGCACGGCTCAACTGATTGACGGCTTCGAATCGCCCTTCG
GCATGGAGTTATTGGCCACAGTTGATTGGCTGTTGAACCAGGAAGGGGTGCCTGCGACTGTTCCTGCAATACGTGAGGCG
TTAAAACGCTGGGATGGCGGTGCCGGTGCTGCGGCTCGCAAAAGCAAGCTGTTCGATGATCAGTCTCTGGAAATTGCGCT
CAAGCGATTGGCTACCAGCAGCTTCCGACCCGAATTAGCGCACTAA

Structures

Toxin

• AlphaFold DB: A0A1M0WJM1