Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3371275..3371893 Replicon chromosome
Accession NZ_CP053720
Organism Escherichia coli strain CP131_Sichuan

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HP434_RS16105 Protein ID WP_001291435.1
Coordinates 3371675..3371893 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HP434_RS16100 Protein ID WP_000344800.1
Coordinates 3371275..3371649 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP434_RS16090 3366364..3367557 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HP434_RS16095 3367580..3370729 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
HP434_RS16100 3371275..3371649 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HP434_RS16105 3371675..3371893 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HP434_RS16110 3372065..3372616 + 552 WP_000102564.1 maltose O-acetyltransferase -
HP434_RS16115 3372732..3373202 + 471 WP_000136192.1 YlaC family protein -
HP434_RS16120 3373366..3374913 + 1548 Protein_3149 cyclic-guanylate-specific phosphodiesterase PdeB -
HP434_RS16125 3374958..3375311 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HP434_RS16135 3375690..3376001 + 312 WP_162001342.1 MGMT family protein -
HP434_RS16140 3376032..3376604 - 573 WP_000779826.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T157541 WP_001291435.1 NZ_CP053720:3371675-3371893 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T157541 NZ_CP069350:c361697-361398 [Shewanella sp. LZH-2]
ATGAATAATAAACGCTATAAACTGAGTAAGTTAGCTCAGACTCACTTACTAAAGATTAAAGACTACACCCTTCAACACTT
TTCTGAGTCGCAGTGGCACAAATACAAAGAAAGCCTAATATCCGGCTTGCAAATGTTAGCCGATAACCCCGGATTAGGCA
GAAGCTGCAACGATATTTACCCCAACGGTTTCTACTTTCCTATCGGTAAACACACCGCCTACTTCACCAAAGAAGACGAC
TTCATCCTCATCGTTGCCCTGTTAGGTCAACCACAGCTACCCCAACATCATCTGAAATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT157541 WP_000344800.1 NZ_CP053720:3371275-3371649 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT157541 NZ_CP069350:c361948-361706 [Shewanella sp. LZH-2]
ATGCAAACCTTAACCGCCAATGACGCCAAACGAAATTTTGGTGAGTTGCTACTAAACGCTCAACGTGAACCCATCAAGAT
CAGCAAAAACAGTAAAGATGCAGTTGTGGTTATGTCTATCCACGATTACGAACAGCTTGAGGCGATGAAAGCCGACTATC
TGAAGCACTGTTTCAACGCAGCCAAAGAAGATTTAGCAAAGGGCAATGTGGTTGATGGCGAAGATTTTCTTAGCGCCCTG
TAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References