Detailed information of TA system TA157525

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 3313548..3314347
• Replicon: chromosome
• Accession: NZ_CP053719
• Organism: Proteus mirabilis strain MPE0346

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A8E3RD10
• Locus tag: HP410_RS15550
• Protein ID: WP_004247966.1
• Coordinates: 3313823..3314347 (+)
• Length: 175 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: B4EVS2
• Locus tag: HP410_RS15545
• Protein ID: WP_004247964.1
• Coordinates: 3313548..3313826 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HP410_RS15520	3308898..3309980	+	1083	WP_004242680.1	peptide chain release factor 1	-
HP410_RS15525	3309980..3310828	+	849	WP_004247962.1	peptide chain release factor N(5)-glutamine methyltransferase	-
HP410_RS15530	3310806..3311621	+	816	WP_004242688.1	invasion regulator SirB1	-
HP410_RS15535	3311679..3312533	+	855	WP_004242689.1	3-deoxy-8-phosphooctulonate synthase	-
HP410_RS15540	3312541..3313470	+	930	WP_017628160.1	TIGR01212 family radical SAM protein	-
HP410_RS15545	3313548..3313826	+	279	WP_004247964.1	DUF1778 domain-containing protein	Antitoxin
HP410_RS15550	3313823..3314347	+	525	WP_004247966.1	hypothetical protein	Toxin
HP410_RS15555	3314428..3316128	-	1701	WP_017628159.1	C4-dicarboxylic acid transporter DauA	-
HP410_RS15565	3317092..3318033	+	942	WP_004242695.1	glyoxylate/hydroxypyruvate reductase GhrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (5-87)

Sequences

Toxin

Protein

• Length: 175 a.a.
• Molecular weight: 19192.12 Da
• Isoelectric Point: 9.3561

>T157525 WP_004247966.1 NZ_CP053719:3313823-3314347 [Proteus mirabilis]
MTIPNWHEEAISKKHNRNGFNCGDAVLNQFLYRHARQNHENGSAKTYLAINNSNNIILGYYSLCPASIEFERTPELIKHG
LARHDIPVFKLARLATDLSVQGKGLGGQLLLAAGRRCLSVASELGGVALLIDAKNERVANWYISYGAIPLLDTPLSLLIS
FKTIYTALSMANKI

Nucleotide

• Length: 525 bp

>T157525 NZ_CP069335:c143255-142974 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10252.82 Da
• Isoelectric Point: 5.1369

>AT157525 WP_004247964.1 NZ_CP053719:3313548-3313826 [Proteus mirabilis]
MAQALVENSERVSIRITTEDKSLLVRAASLENTNLTEFVLRNIVPVARQVIENNERLKLSEKDTLRVMELLDNPPKPNAK
LLAAAFALPDNA

Nucleotide

• Length: 279 bp

>AT157525 NZ_CP069335:c143479-143252 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Antitoxin

• AlphaFold DB: B4EVS2