Detailed information of TA system TA157524

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3033708..3034353
• Replicon: chromosome
• Accession: NZ_CP053719
• Organism: Proteus mirabilis strain MPE0346

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: B4ET86
• Locus tag: HP410_RS14090
• Protein ID: WP_004247035.1
• Coordinates: 3034168..3034353 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B4ET85
• Locus tag: HP410_RS14085
• Protein ID: WP_004247034.1
• Coordinates: 3033708..3034121 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HP410_RS14055	3029261..3029419	-	159	WP_004247025.1	hypothetical protein	-
HP410_RS14060	3029871..3030047	+	177	WP_004247793.1	hypothetical protein	-
HP410_RS14065	3030218..3030964	-	747	WP_017628402.1	methyltransferase domain-containing protein	-
HP410_RS14070	3031814..3032392	+	579	WP_017628400.1	alpha/beta hydrolase	-
HP410_RS14075	3032505..3032798	-	294	Protein_2724	LysE family transporter	-
HP410_RS14080	3033112..3033612	-	501	WP_004247032.1	response regulator	-
HP410_RS14085	3033708..3034121	-	414	WP_004247034.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HP410_RS14090	3034168..3034353	-	186	WP_004247035.1	type II toxin-antitoxin system HicA family toxin	Toxin
HP410_RS14095	3034464..3035234	+	771	Protein_2728	DUF1073 domain-containing protein	-
HP410_RS14100	3035793..3036344	-	552	WP_017628396.1	PH domain-containing protein	-
HP410_RS14105	3036408..3036722	-	315	WP_017628395.1	hypothetical protein	-
HP410_RS14115	3037129..3038862	-	1734	WP_017628394.1	LPS biosynthesis-modulating metalloenzyme YejM	-
HP410_RS14120	3038886..3039113	-	228	WP_004247042.1	YejL family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3023833..3046335	22502

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7049.30 Da
• Isoelectric Point: 10.9659

>T157524 WP_004247035.1 NZ_CP053719:c3034353-3034168 [Proteus mirabilis]
MKSSELIKLLEKNGWILDRIKGSHHQFTHPDFSFVVTVPHPRKDLKKGTLNQIIKSAKLKN

Nucleotide

• Length: 186 bp

>T157524 NZ_CP069334:c5293900-5293622 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15251.98 Da
• Isoelectric Point: 4.3830

>AT157524 WP_004247034.1 NZ_CP053719:c3034121-3033708 [Proteus mirabilis]
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI

Nucleotide

• Length: 414 bp

>AT157524 NZ_CP069334:c5293610-5293305 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Structures

Toxin

• AlphaFold DB: B4ET86

Antitoxin

• AlphaFold DB: B4ET85