Detailed information of TA system TA157507

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/RHH(antitoxin)
• Location: 10279..10832
• Replicon: plasmid unnamed8
• Accession: NZ_CP053715
• Organism: Lichenicola cladoniae strain PAMC 26569

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HN018_RS28260
• Protein ID: WP_171837341.1
• Coordinates: 10279..10572 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HN018_RS28265
• Protein ID: WP_171837342.1
• Coordinates: 10560..10832 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HN018_RS28235 (HN018_28250)	5797..6120	-	324	WP_171837338.1	type II toxin-antitoxin system PemK/MazF family toxin	-
HN018_RS28240 (HN018_28255)	6117..6341	-	225	WP_171837339.1	antitoxin MazE family protein	-
HN018_RS28245 (HN018_28260)	6712..7821	+	1110	WP_171837340.1	ATP-binding protein	-
HN018_RS28250 (HN018_28265)	7818..8567	+	750	WP_239479510.1	DUF4435 domain-containing protein	-
HN018_RS28255 (HN018_28270)	8819..9951	+	1133	Protein_8	IS3 family transposase	-
HN018_RS28260 (HN018_28275)	10279..10572	-	294	WP_171837341.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HN018_RS28265 (HN018_28280)	10560..10832	-	273	WP_171837342.1	CopG family ribbon-helix-helix protein	Antitoxin
HN018_RS28270 (HN018_28285)	10954..11475	+	522	WP_171837343.1	hypothetical protein	-
HN018_RS28275 (HN018_28290)	11507..12163	-	657	WP_171837344.1	hypothetical protein	-
HN018_RS28280 (HN018_28295)	12786..13838	-	1053	WP_171837345.1	hypothetical protein	-
HN018_RS28285 (HN018_28300)	14031..14303	+	273	WP_171837346.1	helix-turn-helix transcriptional regulator	-
HN018_RS28290 (HN018_28305)	14526..15233	+	708	WP_171837347.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..28800	28800

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10676.16 Da
• Isoelectric Point: 5.1665

>T157507 WP_171837341.1 NZ_CP053715:c10572-10279 [Lichenicola cladoniae]
VPRVVVTAGAVRGLERCRQFLAEKDSRAAGRAGSLIERQFLLLEGSPEIGRPLDEQPELRELVIGFGEAGYVALYQYAPG
DEAVFVLAFRHQKEAGY

Nucleotide

• Length: 294 bp

>T157507 NZ_CP069331:c5181060-5180191 [Pseudomonas aeruginosa]
ATGAACATGGCGCAGACCCACACCCCCGTCCCGAACCTGCAACAGCGCTTTCCCGAGCGGCTGGTGCAACTGGCCGACGG
CGCCCAGCTGGCCATCCGCGAATGCGGCCAGGGCCCGGTGGTGGTGCTGTTGCACGGCATCGGTTCGGGCTCGGCGTCCT
GGCTGCATTGCGCCCAGCGCCTGGCCGCCGGCAATCGGGTGATCGCCTGGGACGCGCCGGGTTACGGCCTGTCCACGCCG
CTGCCGCCGGCCCGGCCCAAGGCCTGCGACTACGCCGCGTGCCTGGAGCTGCTGCTGGATGCGCTGGGCGTGGAGAGCTG
CCTGCTGGTGGGCCACTCCCTCGGCGCGCTGATGGCCACGGCCTACGCCGCCGGCATCGGCGCGGCGCGGGTGCGCCGCC
TGGTGCTGCTCAGCCCGGCGCGCGGCTACGGCGCCGCCGAGCTGCGCGACAGCGGCGCCCAGGTGCGCCGCCAGCGCCTG
GAGAACCTGGAGCGCTTCGGTATCGACGGCATGGCCAGCGAGCGCACCGCGCGCCTGCTCGGCCGCAACCCCAGCGAGGA
GGCCCTGGCCTGGGTGCGCTGGAACATGGCGCGGCTCAACCCCGAGGGCTACCGCCAGGCCGTCGAGCTGCTCTGCGGCG
ACGACCTGCTGGGCAACGGGCAGCCTGCCGCTCCTTGCGAGGTGCATTGCGGCGAGGACGACGGCATCACCACGCCCGAG
AGTTGCGGCGCCATCGCCCGCCAGCTCGGCGCGTCGTTCTCGTCGATTCCCGGGGCCGGCCACGCCAGCCCGATCGAACA
ACCCGAAGTGGTCGCAGGACGCATCGGCCACGCGCAACGCCTCTCTCTTGAAGGAACCGCCAATGGATAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10364.38 Da
• Isoelectric Point: 5.1375

>AT157507 WP_171837342.1 NZ_CP053715:c10832-10560 [Lichenicola cladoniae]
MAVSVKLDDALKGRVQHLAASQRRTSHWIMREAIQQYVEREEARESFRQEALASWAEYQETGQHLTGDETRTWLQGWGNG
PETDAPPCHE

Nucleotide

• Length: 273 bp

>AT157507 NZ_CP069331:c5180198-5179365 [Pseudomonas aeruginosa]
ATGGATAAGTCAGACGATTCGCAAGACAAGTACATCGTGCCTGGCCTCGAACGCGGCCTGCTGCTGCTCTGCGAGTTCAG
CCGGAAGGACCGTACCCTGACGGCGCCGGAGTTGGCGCGGCGCCTGAAGCTGCCGCGCTCGACCATCTTCCGCCTGCTGA
CCACCCTGGAGGCCATGGGCTTCGTCACCCGCAACGGCAACGAGTACCGCCTGGGCATGGCGGTGTTGCGCCTGGGCTTC
GAGTACCTGGCCTCGCTGGAGCTGACCGAACTCGGCCAGCCGCTGCTGAACCGCCTGTGCGACGAGATCCGCTACCCCTG
CAACCTGGTGGTGCGCGACGGCCGTTCGATCGTCTACGTGGCCAAGGTTTCGCCGTCCACCCCGCTGAGCAGCTCGGTGA
ACGTCGGGACCCGGTTGCCGGCCCACGCCACGGTGCTCGGCCGCATCCTGCTGCAGGACCTGAGCCTGGGCGAGCTGCGC
GAGCTGTACCCGGAGGAGCAGCTGGAGCAGTTCTCGCCGAACACCCCGCGCAGCGTGCTGGAACTCTTCGACATGGTCCA
GGGCGACCGCCAGCGTGGCTTCGTCCAGGGCGAGGGGTTCTTCGAGGCGAGCATCTCCACCGTCGCGGCGCCGGTACGTG
ATCACAGCGGTCGCGTCATCGCGGCGATGGGGGCGACCATCGCCGCCGGGCATATCGACCCGGAACGCATCGAGGGACTG
GTCAGCCGGGTGCGCAGCAGCGCCGACGAGCTGTCGTACCTGCTCGACTACCGCGCCGACGGCCAGGACAACGTCACCCC
GATCTTCCGGAGTCGCCCGCATGAAACCGTATGA