Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 5797..6341 Replicon plasmid unnamed8
Accession NZ_CP053715
Organism Lichenicola cladoniae strain PAMC 26569

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HN018_RS28235 Protein ID WP_171837338.1
Coordinates 5797..6120 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HN018_RS28240 Protein ID WP_171837339.1
Coordinates 6117..6341 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HN018_RS28220 (HN018_28235) 1034..2002 + 969 WP_171837335.1 tyrosine-type recombinase/integrase -
HN018_RS28225 (HN018_28240) 1947..4109 + 2163 WP_171837336.1 AAA family ATPase -
HN018_RS28230 (HN018_28245) 4242..5726 - 1485 WP_171837337.1 hypothetical protein -
HN018_RS28235 (HN018_28250) 5797..6120 - 324 WP_171837338.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HN018_RS28240 (HN018_28255) 6117..6341 - 225 WP_171837339.1 antitoxin MazE family protein Antitoxin
HN018_RS28245 (HN018_28260) 6712..7821 + 1110 WP_171837340.1 ATP-binding protein -
HN018_RS28250 (HN018_28265) 7818..8567 + 750 WP_239479510.1 DUF4435 domain-containing protein -
HN018_RS28255 (HN018_28270) 8819..9951 + 1133 Protein_8 IS3 family transposase -
HN018_RS28260 (HN018_28275) 10279..10572 - 294 WP_171837341.1 type II toxin-antitoxin system RelE/ParE family toxin -
HN018_RS28265 (HN018_28280) 10560..10832 - 273 WP_171837342.1 CopG family ribbon-helix-helix protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..28800 28800


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-103)

Antitoxin

Antitoxin MazE-like

(9-72)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11556.50 Da        Isoelectric Point: 8.8765

>T157506 WP_171837338.1 NZ_CP053715:c6120-5797 [Lichenicola cladoniae]
VRRGDLVTVALQGEQGKPRPALVVQADHFSDLPAITVLPITSTLIEAPLLRIPIEPNERNGLTKSSQIMVDKPQTPPRNK
VGPTFGHLDDMTMVAVNRALALFLGLA

Download         Length: 324 bp

>T157506 NZ_CP069331:c4912116-4911529 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAGTTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8080.90 Da        Isoelectric Point: 6.9766

>AT157506 WP_171837339.1 NZ_CP053715:c6341-6117 [Lichenicola cladoniae]
MAATGTGAQRVQRRRDKLKAAGLRPVQIWVPDTRAPGFAQECARQSRMIQAAEGQDDPDHDAWSDATDTSGWTA

Download         Length: 225 bp

>AT157506 NZ_CP069331:c4911462-4910608 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTAGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTAGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAACAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGTTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGCGAGACGATGCTCGCTCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGCGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCTCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGACAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGGGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCGTCCTTGACGACATACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References