Detailed information of TA system TA157505

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 386234..386865
• Replicon: plasmid unnamed1
• Accession: NZ_CP053709
• Organism: Lichenicola cladoniae strain PAMC 26569

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HN018_RS23755
• Protein ID: WP_171833822.1
• Coordinates: 386234..386626 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HN018_RS23760
• Protein ID: WP_171833821.1
• Coordinates: 386623..386865 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HN018_RS23740 (HN018_23750)	382947..383546	-	600	Protein_384	hypothetical protein	-
HN018_RS23745 (HN018_23755)	383543..384499	-	957	WP_239479413.1	DUF3991 and toprim domain-containing protein	-
HN018_RS23750 (HN018_23760)	385213..386124	+	912	WP_171833823.1	hypothetical protein	-
HN018_RS23755 (HN018_23765)	386234..386626	-	393	WP_171833822.1	type II toxin-antitoxin system VapC family toxin	Toxin
HN018_RS23760 (HN018_23770)	386623..386865	-	243	WP_171833821.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
HN018_RS23765 (HN018_23775)	387358..388245	-	888	Protein_389	IS3 family transposase	-
HN018_RS23770 (HN018_23780)	388262..389617	-	1356	WP_171837741.1	IS110 family transposase	-
HN018_RS23780 (HN018_23790)	390181..390480	-	300	WP_171837739.1	hypothetical protein	-
HN018_RS23785 (HN018_23795)	390617..390784	-	168	WP_171837738.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..441110	441110
	-	flank	IS/Tn	-	-	387358..388218	860

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• SpoVT-AbrB domain (7-43)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14191.43 Da
• Isoelectric Point: 8.0506

>T157505 WP_171833822.1 NZ_CP053709:c386626-386234 [Lichenicola cladoniae]
MKYLLDTNAVISLLKAQPMLSGRIRKHAPADFGLPAVVAHELFYGAYKSQKRAANLAVVEALQFEVLEFDKEDARQAGAI
RAVLTSAGKSIGPCDVLIAGQTRARGLILITHNTSEFARVDGLKIEDWEI

Nucleotide

• Length: 393 bp

>T157505 NZ_CP069331:c3341476-3340898 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9099.24 Da
• Isoelectric Point: 4.8304

>AT157505 WP_171833821.1 NZ_CP053709:c386865-386623 [Lichenicola cladoniae]
VETAKVFWSGRSQAVRLPKAFRLEQDEVRIRRHGSAVILEPIPTNWAWLDAIAGSVDPDFEHAAGEKIPEQERPELGFFE

Nucleotide

• Length: 243 bp

>AT157505 NZ_CP069331:c3342119-3341565 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA