157504

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4250991..4251565 Replicon chromosome
Accession NZ_CP053708
Organism Lichenicola cladoniae strain PAMC 26569

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HN018_RS19180 Protein ID WP_171835817.1
Coordinates 4250991..4251182 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HN018_RS19185 Protein ID WP_171835818.1
Coordinates 4251185..4251565 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HN018_RS29125 4246730..4246858 + 129 WP_275434156.1 hypothetical protein -
HN018_RS19165 (HN018_19175) 4246903..4247976 - 1074 WP_171835816.1 hypothetical protein -
HN018_RS28475 (HN018_19180) 4248064..4249728 - 1665 WP_204259580.1 catalase family protein -
HN018_RS19175 (HN018_19185) 4249990..4250940 - 951 WP_275434157.1 4-hydroxy-2-oxoheptanedioate aldolase -
HN018_RS19180 (HN018_19190) 4250991..4251182 + 192 WP_171835817.1 type II toxin-antitoxin system HicA family toxin Toxin
HN018_RS19185 (HN018_19195) 4251185..4251565 + 381 WP_171835818.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HN018_RS19190 (HN018_19200) 4251749..4252354 - 606 WP_171835819.1 methionine biosynthesis protein MetW -
HN018_RS19195 (HN018_19205) 4252359..4253528 - 1170 WP_171835820.1 homoserine O-acetyltransferase -
HN018_RS19200 (HN018_19210) 4253836..4254861 + 1026 WP_171835821.1 glycoside hydrolase family 99-like domain-containing protein -
HN018_RS19205 (HN018_19215) 4255063..4255311 - 249 WP_171835822.1 hypothetical protein -
HN018_RS19210 (HN018_19220) 4255371..4255628 - 258 WP_171835823.1 helix-turn-helix transcriptional regulator -
HN018_RS19215 (HN018_19225) 4255883..4256524 + 642 WP_172443496.1 DUF433 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-119)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7147.31 Da        Isoelectric Point: 11.4111

>T157504 WP_171835817.1 NZ_CP053708:4250991-4251182 [Lichenicola cladoniae]
VDSRQIIAALQVDGWSHVATKGDHWQFKHPIKSGRVTVPHPKRDLPIGTLKSIEKQARLKLRT

Download         Length: 192 bp

>T157504 NZ_CP069331:2362145-2362900 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGCTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGTGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13670.38 Da        Isoelectric Point: 4.6364

>AT157504 WP_171835818.1 NZ_CP053708:4251185-4251565 [Lichenicola cladoniae]
MATYIALLRKDASSDYGVDFPDLPGCVTAGRTLEEARIAAAEALSLHLEGLAEDGEAAPEPSSTDQVMADPHNRDAVAFL
VDAAPSTKPVRVNVMLPSDLLRRIDQTTRNRSRFLAEAAREKLEHI

Download         Length: 381 bp

>AT157504 NZ_CP069331:2361642-2362010 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCCGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCTTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References