157503

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3816753..3817460 Replicon chromosome
Accession NZ_CP053708
Organism Lichenicola cladoniae strain PAMC 26569

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HN018_RS17265 Protein ID WP_171832920.1
Coordinates 3817050..3817460 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HN018_RS17260 Protein ID WP_275434130.1
Coordinates 3816753..3817040 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HN018_RS17245 (HN018_17255) 3812803..3813399 + 597 WP_171832923.1 hypothetical protein -
HN018_RS17250 (HN018_17260) 3813650..3814951 - 1302 WP_204259562.1 cytochrome P450 -
HN018_RS17255 (HN018_17265) 3815133..3816650 - 1518 WP_171832921.1 NADH-quinone oxidoreductase subunit M -
HN018_RS17260 (HN018_17270) 3816753..3817040 + 288 WP_275434130.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HN018_RS17265 (HN018_17275) 3817050..3817460 + 411 WP_171832920.1 tRNA(fMet)-specific endonuclease VapC Toxin
HN018_RS17270 (HN018_17280) 3817463..3819298 - 1836 WP_171832919.1 DNA mismatch repair endonuclease MutL -
HN018_RS17275 (HN018_17285) 3819503..3820045 - 543 WP_171832918.1 DUF3035 domain-containing protein -
HN018_RS17280 (HN018_17290) 3820119..3820937 - 819 WP_171832917.1 aldo/keto reductase -
HN018_RS17285 (HN018_17295) 3821002..3821535 - 534 WP_171832916.1 signal peptidase II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-115)

Antitoxin

SpoVT-AbrB domain

(30-75)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15336.61 Da        Isoelectric Point: 6.8543

>T157503 WP_171832920.1 NZ_CP053708:3817050-3817460 [Lichenicola cladoniae]
MLRYMLDTNLCIRVIRDRPAWLRPRFNAEAAGLCLSSVVLYELLYGAERSARPAETRQQVERFASRLTLLPFDDEAAAHS
AIIRAELERQSHVIGPYDLMIAGHARSRGLVVVTGNLVEFQCVAGLRSEDWLHEAS

Download         Length: 411 bp

>T157503 NZ_CP069331:1501327-1501605 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10471.06 Da        Isoelectric Point: 8.6016

>AT157503 WP_275434130.1 NZ_CP053708:3816753-3817040 [Lichenicola cladoniae]
MPMLAPVELKGYTSYISQEGVVGMRTKLFLSNRSQAVRLPKAVAFPGTVTEVAIVRDGVRRIIVPADATWDDFFEAAGVD
LGPRTQPAHQQREPF

Download         Length: 288 bp

>AT157503 NZ_CP069331:1501617-1501922 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References