Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2522975..2523527 Replicon chromosome
Accession NZ_CP053707
Organism Arthrobacter sp. NEB 688

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HL663_RS11785 Protein ID WP_173028564.1
Coordinates 2522975..2523289 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HL663_RS11790 Protein ID WP_173028565.1
Coordinates 2523294..2523527 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HL663_RS11760 2518501..2520291 - 1791 WP_173028559.1 long-chain fatty acid--CoA ligase -
HL663_RS11765 2520366..2520809 + 444 WP_173028560.1 SRPBCC family protein -
HL663_RS11770 2520818..2521180 + 363 WP_173028561.1 hypothetical protein -
HL663_RS11775 2521137..2522213 + 1077 WP_173028562.1 ROK family glucokinase -
HL663_RS11780 2522225..2522908 + 684 WP_173028563.1 endonuclease/exonuclease/phosphatase family protein -
HL663_RS11785 2522975..2523289 - 315 WP_173028564.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HL663_RS11790 2523294..2523527 - 234 WP_173028565.1 ribbon-helix-helix domain-containing protein Antitoxin
HL663_RS11795 2523585..2524142 - 558 WP_173028566.1 hypothetical protein -
HL663_RS11800 2524288..2525094 + 807 WP_173028567.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
HL663_RS11805 2525103..2526284 + 1182 WP_173028568.1 histidine kinase -
HL663_RS11810 2526236..2526982 + 747 WP_173028569.1 response regulator transcription factor -
HL663_RS11815 2527023..2528405 + 1383 WP_173028570.1 3-deoxy-7-phosphoheptulonate synthase class II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-93)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11011.80 Da        Isoelectric Point: 5.8099

>T157501 WP_173028564.1 NZ_CP053707:c2523289-2522975 [Arthrobacter sp. NEB 688]
VREICLVRLDKTRPALVLTREAARGAMTKVTVAPITSTVKGLSSEVLVGPENGLDHRCAVSLDNVLTVPVGALGRTIGYL
GAEQETQLARAVVLAYDLDLSVLD

Download         Length: 315 bp

>T157501 NZ_CP069330:c5248460-5248182 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8454.54 Da        Isoelectric Point: 4.4665

>AT157501 WP_173028565.1 NZ_CP053707:c2523527-2523294 [Arthrobacter sp. NEB 688]
MSTQIAVRLPDELVAFLDRSVAAGKAPSRAALVTAAVEREMRRLAAEQDAHLLRTRGAEDDLDELVEWTGTHVVLED

Download         Length: 234 bp

>AT157501 NZ_CP069330:c5248170-5247865 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References