Detailed information of TA system TA157500

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1509252..1509796
• Replicon: chromosome
• Accession: NZ_CP053707
• Organism: Arthrobacter sp. NEB 688

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HL663_RS07185
• Protein ID: WP_173027714.1
• Coordinates: 1509515..1509796 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HL663_RS07180
• Protein ID: WP_173027713.1
• Coordinates: 1509252..1509518 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HL663_RS07165	1505150..1506469	-	1320	WP_173027711.1	MFS transporter	-
HL663_RS07170	1506508..1507665	+	1158	WP_173030047.1	alanine racemase	-
HL663_RS07175	1507650..1508966	+	1317	WP_173027712.1	FAD-binding protein	-
HL663_RS07180	1509252..1509518	+	267	WP_173027713.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HL663_RS07185	1509515..1509796	+	282	WP_173027714.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HL663_RS07190	1509836..1510723	-	888	WP_173030048.1	cysteine synthase CysM	-
HL663_RS07195	1510800..1511810	-	1011	WP_173027715.1	ATP-binding protein	-
HL663_RS07200	1511900..1512187	-	288	WP_173027716.1	hypothetical protein	-
HL663_RS07205	1512305..1512964	+	660	WP_173030049.1	alpha/beta hydrolase	-
HL663_RS07210	1512980..1513243	-	264	WP_173027717.1	metal-binding protein	-
HL663_RS07215	1513293..1513826	-	534	WP_173030050.1	excalibur calcium-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (34-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10376.02 Da
• Isoelectric Point: 10.3791

>T157500 WP_173027714.1 NZ_CP053707:1509515-1509796 [Arthrobacter sp. NEB 688]
VSDVAPYELVLTPPAVRAIRSGLPEAVAAAVVEFLTGALVDNPQRVGKPLRADLAGIHAARRGTYRVLYRIHEEAREVVV
LRIDHRREVYRPR

Nucleotide

• Length: 282 bp

>T157500 NZ_CP069330:c4387658-4386903 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGCTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGTGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9735.87 Da
• Isoelectric Point: 4.4698

>AT157500 WP_173027713.1 NZ_CP053707:1509252-1509518 [Arthrobacter sp. NEB 688]
MSVEPLREVRDHFSDVVDRVEREHERVTVTRNGRAAAVIISPEDLAELEETLSVLSDPRALADIREADAAYASGDVVRGV
DVVRALRP

Nucleotide

• Length: 267 bp

>AT157500 NZ_CP069330:c4388161-4387793 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCCGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCTTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA