Detailed information of TA system TA157496

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 5661756..5662261
• Replicon: chromosome
• Accession: NZ_CP053706
• Organism: Pseudomonas aeruginosa strain PAC1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: HPT09_RS26130
• Protein ID: WP_003083773.1
• Coordinates: 5661756..5662037 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: HPT09_RS26135
• Protein ID: WP_003083775.1
• Coordinates: 5662034..5662261 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPT09_RS26105	5657007..5658356	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
HPT09_RS26110	5658405..5659091	+	687	WP_003083762.1	FadR family transcriptional regulator	-
HPT09_RS26115	5659192..5659926	+	735	WP_003117208.1	GntR family transcriptional regulator	-
HPT09_RS26120	5660130..5660516	+	387	WP_014602345.1	aegerolysin family protein	-
HPT09_RS26125	5660548..5661456	-	909	WP_010793581.1	LysR family transcriptional regulator	-
HPT09_RS26130	5661756..5662037	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
HPT09_RS26135	5662034..5662261	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
HPT09_RS26140	5662437..5663057	-	621	WP_003101226.1	hypothetical protein	-
HPT09_RS26145	5663158..5663658	+	501	WP_003101228.1	LEA type 2 family protein	-
HPT09_RS26150	5663731..5664072	+	342	WP_003101229.1	alkylphosphonate utilization protein	-
HPT09_RS26155	5664154..5665581	-	1428	WP_003083784.1	GABA permease	-
HPT09_RS26160	5665750..5667243	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T157496 WP_003083773.1 NZ_CP053706:c5662037-5661756 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T157496 NZ_CP069330:c143233-142952 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT157496 WP_003083775.1 NZ_CP053706:c5662261-5662034 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT157496 NZ_CP069330:c143457-143230 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9