Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1141337..1141830 Replicon chromosome
Accession NZ_CP053704
Organism Enterococcus faecium strain FS 86

Toxin (Protein)


Gene name relE Uniprot ID A0A829A9S0
Locus tag HPK29_RS05540 Protein ID WP_002342567.1
Coordinates 1141564..1141830 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A829AAJ0
Locus tag HPK29_RS05535 Protein ID WP_002329324.1
Coordinates 1141337..1141567 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPK29_RS05510 1136808..1137134 + 327 Protein_1091 hypothetical protein -
HPK29_RS05515 1137209..1138371 + 1163 WP_087628202.1 IS3 family transposase -
HPK29_RS05520 1138830..1139420 - 591 WP_002342564.1 glutamine amidotransferase -
HPK29_RS05525 1140208..1140513 + 306 WP_002342565.1 hypothetical protein -
HPK29_RS05530 1140526..1140861 + 336 WP_002329326.1 hypothetical protein -
HPK29_RS05535 1141337..1141567 + 231 WP_002329324.1 hypothetical protein Antitoxin
HPK29_RS05540 1141564..1141830 + 267 WP_002342567.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPK29_RS05545 1142082..1142309 + 228 WP_002329322.1 hypothetical protein -
HPK29_RS05550 1142325..1143491 + 1167 WP_002329321.1 oxygen-independent coproporphyrinogen III oxidase -
HPK29_RS05555 1143724..1144767 + 1044 WP_073441383.1 heat-inducible transcriptional repressor HrcA -
HPK29_RS05560 1144861..1145424 + 564 WP_002292135.1 nucleotide exchange factor GrpE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10651.28 Da        Isoelectric Point: 10.1925

>T157484 WP_002342567.1 NZ_CP053704:1141564-1141830 [Enterococcus faecium]
MTYRLEFTPEIQKQLRKMDKHQATLIVRWLYQHIDGIDDPRKFGKGFTANRSGQWRYRIGKYRVLVEIEDDQMVVIAIQV
GHRRNIYD

Download         Length: 267 bp

>T157484 NZ_CP069328:c143243-142962 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8863.97 Da        Isoelectric Point: 4.1938

>AT157484 WP_002329324.1 NZ_CP053704:1141337-1141567 [Enterococcus faecium]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWVESGKTTVSMEEILHEFGGLE

Download         Length: 231 bp

>AT157484 NZ_CP069328:c143467-143240 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829A9S0

Antitoxin

Source ID Structure
AlphaFold DB A0A829AAJ0

References