Detailed information of TA system TA157459

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 496534..498256
• Replicon: chromosome
• Accession: NZ_CP053685
• Organism: Proteus mirabilis strain MPE5203

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A0U2S2I2
• Locus tag: HOY68_RS02170
• Protein ID: WP_064497040.1
• Coordinates: 496534..497472 (-)
• Length: 313 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A934MVJ4
• Locus tag: HOY68_RS02175
• Protein ID: WP_000095577.1
• Coordinates: 497465..498256 (-)
• Length: 264 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HOY68_RS02150	492475..492987	-	513	WP_175215521.1	S26 family signal peptidase	-
HOY68_RS02155	492971..493318	-	348	WP_064497038.1	hypothetical protein	-
HOY68_RS02160	493311..495710	-	2400	WP_064497039.1	type IV secretion system protein TraC	-
HOY68_RS02165	495710..496402	-	693	WP_001228924.1	DsbC family protein	-
HOY68_RS02170	496534..497472	-	939	WP_064497040.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
HOY68_RS02175	497465..498256	-	792	WP_000095577.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
HOY68_RS02180	498477..498863	-	387	WP_032469918.1	hypothetical protein	-
HOY68_RS02185	498860..499432	-	573	WP_024008834.1	type IV conjugative transfer system lipoprotein TraV	-
HOY68_RS02190	499507..500796	-	1290	WP_064497041.1	TraB/VirB10 family protein	-
HOY68_RS02195	500799..501695	-	897	WP_064497055.1	type-F conjugative transfer system secretin TraK	-
HOY68_RS02200	501679..502305	-	627	WP_064497042.1	pilus assembly protein	-
HOY68_RS02205	502302..502583	-	282	WP_000433891.1	type IV conjugative transfer system protein TraL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(J) / aadA2 / ere(A) / sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / aph(3')-Ia / tet(C) / sul2 / aph(3'')-Ib / aph(6)-Id / floR	-	372221..571819	199598

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-272)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (99-250)

Sequences

Toxin

Protein

• Length: 313 a.a.
• Molecular weight: 35542.81 Da
• Isoelectric Point: 4.9912

>T157459 WP_064497040.1 NZ_CP053685:c497472-496534 [Proteus mirabilis]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIIVSSPVATIKIEVSPVARGTLHSAEIMAVQESVEYEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGVSREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLTSLQK
HFTERDYAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Nucleotide

• Length: 939 bp

>T157459 NZ_CP069323:c5247764-5247486 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin

Protein

• Length: 264 a.a.
• Molecular weight: 30109.49 Da
• Isoelectric Point: 9.5097

>AT157459 WP_000095577.1 NZ_CP053685:c498256-497465 [Proteus mirabilis]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Nucleotide

• Length: 792 bp

>AT157459 NZ_CP069323:c5247474-5247169 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Structures

Toxin

• AlphaFold DB: A0A0U2S2I2