Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 3853532..3855254 Replicon chromosome
Accession NZ_CP053684
Organism Proteus mirabilis strain MPE5139

Toxin (Protein)


Gene name mosT Uniprot ID A0A1L5JQJ1
Locus tag HOW74_RS18055 Protein ID WP_000356586.1
Coordinates 3853532..3854470 (-) Length 313 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A0M0HVB9
Locus tag HOW74_RS18060 Protein ID WP_002026815.1
Coordinates 3854463..3855254 (-) Length 264 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HOW74_RS18040 3848982..3849119 - 138 WP_175223899.1 hypothetical protein -
HOW74_RS18045 3849132..3850241 - 1110 WP_000076135.1 hypothetical protein -
HOW74_RS18050 3850238..3852967 - 2730 WP_001901413.1 AAA family ATPase -
HOW74_RS18055 3853532..3854470 - 939 WP_000356586.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
HOW74_RS18060 3854463..3855254 - 792 WP_002026815.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
HOW74_RS18065 3855474..3855860 - 387 WP_000180225.1 hypothetical protein -
HOW74_RS18070 3855857..3856429 - 573 WP_001901415.1 type IV conjugative transfer system lipoprotein TraV -
HOW74_RS18075 3856504..3857793 - 1290 WP_000647307.1 TraB/VirB10 family protein -
HOW74_RS18080 3857793..3858692 - 900 WP_001901416.1 type-F conjugative transfer system secretin TraK -
HOW74_RS18085 3858676..3859302 - 627 WP_000667167.1 hypothetical protein -
HOW74_RS18090 3859299..3859580 - 282 WP_000433889.1 type IV conjugative transfer system protein TraL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(J) / dfrA1 / sul2 / aph(3'')-Ib - 3745759..3891445 145686
- flank IS/Tn - - 3847997..3848917 920


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-97)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 35482.75 Da        Isoelectric Point: 5.0041

>T157458 WP_000356586.1 NZ_CP053684:c3854470-3853532 [Proteus mirabilis]
MDKDSPYYKQVSLLIRMLPVVATERVFALKGGTAINLFVRDIPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLDEKFQAEFDGMTFEKVECEDLASVRPIMLTALQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Download         Length: 939 bp

>T157458 NZ_CP069323:c4386934-4386179 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGCTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGTGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 264 a.a.        Molecular weight: 30116.50 Da        Isoelectric Point: 9.1901

>AT157458 WP_002026815.1 NZ_CP053684:c3855254-3854463 [Proteus mirabilis]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLCSGVYYRPDAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Download         Length: 792 bp

>AT157458 NZ_CP069323:c4387437-4387069 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCCGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCTTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L5JQJ1

Antitoxin

Source ID Structure
AlphaFold DB A0A0M0HVB9

References