Detailed information of TA system TA157454

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 505768..506369
• Replicon: chromosome
• Accession: NZ_CP053684
• Organism: Proteus mirabilis strain MPE5139

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: HOW74_RS02300
• Protein ID: WP_049194960.1
• Coordinates: 505768..506151 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A1Z1SPN9
• Locus tag: HOW74_RS02305
• Protein ID: WP_004246496.1
• Coordinates: 506148..506369 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HOW74_RS02275	501140..501598	+	459	WP_004249766.1	GNAT family N-acetyltransferase	-
HOW74_RS02280	501694..502431	-	738	WP_004249950.1	sel1 repeat family protein	-
HOW74_RS02285	502540..503439	+	900	WP_109023958.1	N-acetylmuramic acid 6-phosphate etherase	-
HOW74_RS02290	503796..505034	-	1239	WP_109023957.1	HipA domain-containing protein	-
HOW74_RS02295	505047..505361	-	315	WP_004246498.1	helix-turn-helix domain-containing protein	-
HOW74_RS02300	505768..506151	-	384	WP_049194960.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
HOW74_RS02305	506148..506369	-	222	WP_004246496.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HOW74_RS02310	506650..507513	-	864	WP_004249947.1	YicC family protein	-
HOW74_RS02315	507640..508356	+	717	WP_004249946.1	ribonuclease PH	-
HOW74_RS02320	508437..509081	+	645	WP_004246493.1	orotate phosphoribosyltransferase	-
HOW74_RS02325	509400..510005	-	606	WP_004246491.1	nucleoid occlusion factor SlmA	-
HOW74_RS02330	510125..510583	-	459	WP_004246490.1	dUTP diphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (5-115)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14462.43 Da
• Isoelectric Point: 6.6451

>T157454 WP_049194960.1 NZ_CP053684:c506151-505768 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQHFPGVAGMSDPGRAEALIYRVQNRKHDEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTDNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Nucleotide

• Length: 384 bp

>T157454 NZ_CP069323:c143237-142956 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8260.23 Da
• Isoelectric Point: 5.5667

>AT157454 WP_004246496.1 NZ_CP053684:c506369-506148 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Nucleotide

• Length: 222 bp

>AT157454 NZ_CP069323:c143461-143234 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1Z1SPN9