Detailed information of TA system TA157453

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 484838..486409
• Replicon: chromosome
• Accession: NZ_CP053684
• Organism: Proteus mirabilis strain MPE5139

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: M9PP16
• Locus tag: HOW74_RS02205
• Protein ID: WP_004249772.1
• Coordinates: 484838..486151 (-)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: B4F0T9
• Locus tag: HOW74_RS02210
• Protein ID: WP_004249771.1
• Coordinates: 486152..486409 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HOW74_RS02185	480007..480810	+	804	WP_004249775.1	energy transducer TonB	-
HOW74_RS02190	480864..482825	-	1962	WP_170837711.1	hypothetical protein	-
HOW74_RS02195	482857..483786	-	930	WP_004246518.1	metallophosphoesterase	-
HOW74_RS02200	483971..484435	-	465	WP_004249773.1	DUF1097 domain-containing protein	-
HOW74_RS02205	484838..486151	-	1314	WP_004249772.1	type II toxin-antitoxin system HipA family toxin	Toxin
HOW74_RS02210	486152..486409	-	258	WP_004249771.1	helix-turn-helix domain-containing protein	Antitoxin
HOW74_RS02215	486558..487922	-	1365	WP_004246513.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
HOW74_RS02220	488060..489700	-	1641	WP_004246512.1	membrane protein insertase YidC	-
HOW74_RS02225	489703..489963	-	261	WP_012368639.1	membrane protein insertion efficiency factor YidD	-
HOW74_RS02230	489927..490286	-	360	WP_004246510.1	ribonuclease P protein component	-
HOW74_RS02235	490304..490447	-	144	WP_004246509.1	50S ribosomal protein L34	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49658.73 Da
• Isoelectric Point: 6.5023

>T157453 WP_004249772.1 NZ_CP053684:c486151-484838 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDTELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Nucleotide

• Length: 1314 bp

>T157453 NZ_CP069321:c124129-123713 [Kosakonia cowanii]
GTGAACAAAACGTATATGCTGGACACGAATATCTGCTCATTCATCATGCGCGAGCAGCCGGAGGCGGTGCTGAAGCGCCT
TGAGCAGGCGGTGCTGCGCGGTCACCGCATCGTGGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGTGCCACCGGCC
CGAAGGCCTCTCCCCGCCACGTGGCGCTGGTTGACGCATTCTGCTCCCGCCTTGATGCCGTGCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACCACGGAAATCCGGGTTGCGCTGCGCCTTGCCGGCACGCCAATTGGCACGAATGACACGGCGATTGC
CGGGCATGCCATCGCGGCCGGTGCCGTGCTGGTGACGAATAATGTGAGGGAGTTTGAGCGGGTGCCGGGCCTCACTCTGG
AAGACTGGGCCGGTTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT157453 WP_004249771.1 NZ_CP053684:c486409-486152 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT157453 NZ_CP069321:c124356-124126 [Kosakonia cowanii]
ATGAGAACCGTATCCATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAAATCGTCCGGGAAGGGGACAGCATCATCCTCCGTCCCGTCCGGCCGACCTGGCGCTCATTCCTGGAGCTCG
AAAAAGCCGATCCGGATTTTATGGCGGAGCGCGAGGGCGTTGTCAGCGACGAAGGACGATTTGACCTGTGA

Structures

Toxin

• AlphaFold DB: M9PP16

Antitoxin

• AlphaFold DB: B4F0T9