Detailed information of TA system TA157452

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 131284..131983
• Replicon: chromosome
• Accession: NZ_CP053684
• Organism: Proteus mirabilis strain MPE5139

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HOW74_RS00570
• Protein ID: WP_017628658.1
• Coordinates: 131284..131670 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: HOW74_RS00575
• Protein ID: WP_004246828.1
• Coordinates: 131663..131983 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HOW74_RS00555	127303..127884	-	582	WP_012368524.1	DNA-3-methyladenine glycosylase I	-
HOW74_RS00560	128135..129040	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
HOW74_RS00565	129050..131122	+	2073	WP_017628659.1	glycine--tRNA ligase subunit beta	-
HOW74_RS00570	131284..131670	+	387	WP_017628658.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HOW74_RS00575	131663..131983	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
HOW74_RS00580	132032..132466	-	435	WP_004246827.1	hypothetical protein	-
HOW74_RS00585	132459..133343	-	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
HOW74_RS00590	133558..134844	-	1287	WP_017628657.1	DUF3748 domain-containing protein	-
HOW74_RS00595	134981..135598	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
HOW74_RS00600	135899..136522	+	624	WP_004246821.1	guanylate kinase	-
HOW74_RS00605	136577..136852	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14322.65 Da
• Isoelectric Point: 10.0826

>T157452 WP_017628658.1 NZ_CP053684:131284-131670 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVRYD

Nucleotide

• Length: 387 bp

>T157452 NZ_CP069321:94261-94731 [Kosakonia cowanii]
TTGATTCTTTACCGGCTGACCAAGACAAAGTATCTTTCTACAGCCTGGACGGGTTACGGTGCAAAAGAAGCCGGAGGCCG
GTGGAACAGTGTCGGTACATCGATGGTTTATGTATCAGACGTGGCATCACTTACCATGCTGGAAACGCTGGTACATCTCC
ATGCGTCACACATCATGGATTATTTCACGTTACTGCGGATTGATGTACCGGACGAGCAGATCCAGAAAGCAGACATGGGC
GAACTGCCGGGTAACTGGGCTGATGAAGAAGCGCCATCAGAGCTGGCAGCATATGGAGATGCATGGTGCTTTACGGGTTC
CTCAATAGCGCTGCGTGTTCCCAGCGCATTATCCCCCGTTGAATTTAACTATCTGCTGAATCCTGAGCACCCGGAATTTT
CCAGCGTAATAAAACATGCTGAAGAAATTCCCTTCAGATTTGACAGTCGGTTGAAACGCGCGCGGCCTTAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT157452 WP_004246828.1 NZ_CP053684:131663-131983 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT157452 NZ_CP069321:93821-94264 [Kosakonia cowanii]
ATGAAAACATTTAACTTTTCCACGATTCAGGCCAGGCCACCCCGCTTATGGCAGGTTGCAGGGTTAAACACTTCGGACGG
AGTTGCATTAGTGGGCCAGATTAATGATGGCCTGGATGGCAGGGTCGCTACCGTAATCGCTGACTGGGCAAAGATGACGC
AGAATGACCTGCGCAAAATGTCAGGCATACCACCCACGACGTATGGACGGGGCCTGAAAGCGCGATTCAGTCCAGATCAG
AGCGAACGACTGGTTCGCATCATCCGTGTCATTGATCGGGCTGTTGACCTGTTTGAAGGGGACAAGGAGGAAGCCCAGAA
GTGGCTGAAGGAACCAAACCGTGGCCTGGGCTGGAAAGTGCCAGCTGAGCTCATGGCATCCGAAACCGGGGCTTATGAAG
TCATGAAGCTGATCACCCGTCTGGAACATGGGGTGTACTCTTGA

Structures

Antitoxin

• AlphaFold DB: B4EZ97