Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1662896..1663497 Replicon chromosome
Accession NZ_CP053683
Organism Proteus mirabilis strain MPE0027

Toxin (Protein)


Gene name doc Uniprot ID A0A2X2BIG8
Locus tag HNV02_RS07720 Protein ID WP_004246497.1
Coordinates 1662896..1663279 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A7D5W489
Locus tag HNV02_RS07725 Protein ID WP_063073826.1
Coordinates 1663276..1663497 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HNV02_RS07700 1658828..1659391 + 564 WP_063073823.1 methyltransferase -
HNV02_RS07705 1659667..1660566 + 900 WP_175233750.1 N-acetylmuramic acid 6-phosphate etherase -
HNV02_RS07710 1660923..1662161 - 1239 WP_175233751.1 HipA domain-containing protein -
HNV02_RS07715 1662174..1662488 - 315 WP_004246498.1 helix-turn-helix domain-containing protein -
HNV02_RS07720 1662896..1663279 - 384 WP_004246497.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HNV02_RS07725 1663276..1663497 - 222 WP_063073826.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HNV02_RS07730 1663742..1664605 - 864 WP_004249947.1 YicC family protein -
HNV02_RS07735 1664732..1665448 + 717 WP_004249760.1 ribonuclease PH -
HNV02_RS07740 1665530..1666174 + 645 WP_004246493.1 orotate phosphoribosyltransferase -
HNV02_RS07745 1666493..1667098 - 606 WP_004246491.1 nucleoid occlusion factor SlmA -
HNV02_RS07750 1667218..1667676 - 459 WP_004246490.1 dUTP diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-115)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14471.53 Da        Isoelectric Point: 8.5125

>T157449 WP_004246497.1 NZ_CP053683:c1663279-1662896 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T157449 NZ_CP069319:4585980-4586270 [Kosakonia cowanii]
ATGAAAGAGATAGTCCAAACCGACGCGTTTAAACTCTGGGAGTCATCATTACGCGATGCGAAATTGCGAGCGATTATCTC
AGCGCGTCTTTTTAGATTGGCAAATGGCCTCACCGGAGATGTGAAACCAGTCGGGGAAGGGATAAGTGAATTACGAATAC
ATTATGGTGCCGGTTACCGCATCTATTTTCAGTTGCGGGGTAATACCGTTGTCGTGTTGTTGTGTGGGGGGGATAAAAGC
ACCCAACCAAAAGACATTATCTATGCCAAATACCTGGCAAAATGTGTTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8290.25 Da        Isoelectric Point: 5.5667

>AT157449 WP_063073826.1 NZ_CP053683:c1663497-1663276 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNTKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT157449 NZ_CP069319:4586288-4586566 [Kosakonia cowanii]
ATGAATAAATTAACCCCTTACGATCCCGCAGCGGCACTGGTTAACGATGAGGCGATAGCACTCTTCATGGCGGATGCGCT
CGAAACCGGCGATGCGGCTTATATCGCCCGAGCATTAGGGGTGATTGCTCGGGCCAAAGGGATGAGCGACATCGCTGCAG
AAACCGGTTTGTCACGCGAGCAGCTCTATCGCTCTTTCAGCGAAAAAGGGAATCCGACACTGAAGACGACACTCTCCGTA
ATGAAAGCGCTGGGCATTGAACTGACAGTCAAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X2BIG8

Antitoxin

Source ID Structure
AlphaFold DB A0A7D5W489

References