Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rnlAB/RnlA-RnlB
Location 1643720..1645157 Replicon chromosome
Accession NZ_CP053683
Organism Proteus mirabilis strain MPE0027

Toxin (Protein)


Gene name rnlA Uniprot ID -
Locus tag HNV02_RS07635 Protein ID WP_129979812.1
Coordinates 1643720..1644790 (+) Length 357 a.a.

Antitoxin (Protein)


Gene name rnlB Uniprot ID -
Locus tag HNV02_RS07640 Protein ID WP_129979813.1
Coordinates 1644792..1645157 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HNV02_RS07610 1638930..1639964 + 1035 WP_175233744.1 virulence RhuM family protein -
HNV02_RS07615 1640022..1640816 - 795 WP_175233745.1 hypothetical protein -
HNV02_RS07620 1641229..1641426 + 198 WP_175233746.1 helix-turn-helix domain-containing protein -
HNV02_RS07625 1641439..1643115 + 1677 WP_175233747.1 DUF927 domain-containing protein -
HNV02_RS07630 1643177..1643521 + 345 WP_175233748.1 helix-turn-helix domain-containing protein -
HNV02_RS07635 1643720..1644790 + 1071 WP_129979812.1 type II toxin-antitoxin system RnlA family toxin Toxin
HNV02_RS07640 1644792..1645157 + 366 WP_129979813.1 type II toxin-antitoxin system RnlB family antitoxin Antitoxin
HNV02_RS07645 1645154..1646323 - 1170 WP_175233749.1 site-specific integrase -
HNV02_RS07650 1646487..1647851 - 1365 WP_004246513.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
HNV02_RS07655 1647989..1649629 - 1641 WP_004246512.1 membrane protein insertase YidC -
HNV02_RS07660 1649632..1649892 - 261 WP_012368639.1 membrane protein insertion efficiency factor YidD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterial toxin, RNase RnlA/LsoA, N-terminal

(5-87)

Antitoxin

Antitoxin RnlB/LsoB

(15-111)


Sequences

Toxin        


Download         Length: 357 a.a.        Molecular weight: 40052.85 Da        Isoelectric Point: 6.2327

>T157448 WP_129979812.1 NZ_CP053683:1643720-1644790 [Proteus mirabilis]
VERSYKNLNLDRAAIKNLVESFATEHQFTIKSISAIPGTQKGTRIVFGRTGNKFATVNVFFNKDGTSTIQYLTGANHDIG
KLMTDHLYGSINPAEFEQVNMVLEGFTESAILPVLEFAAEESHIKVVVHAQDEHKTVWKIRSEEYQDELTVTLHIRTDKL
QIQGRPLSCYRVFIFNLSELLDLQGLEKVLIRQEDGNAEIVQQEVARSYLQSVLGESYERLHSNVEKLLISGLCVKLASP
NLPDYCMLLYPELRSIEGALKSKFMALGIEVGKDGFGDFFVKDQGVHVLNADCAALCANAEAAKIISEAYTFYNRERHGL
FHMEALVEASRMISNIAHLMTKSTQAWDLIKKLYSI

Download         Length: 1071 bp

>T157448 NZ_CP069319:c4339899-4339615 [Kosakonia cowanii]
ATGATCTATGAGCTGGCGTTTGATCCGCGCGCGTTGAAAGAGTGGAAAAAACTGGGCGTGACGGTTCAGGCGCAGTTTAA
AAAGAAGCTCGCAGAAGTGCTGGTTCAGCCGAGAGTAGAAAAAGCCCGGCTGCATGGCTTGCCGGATTGCTACAAGATAA
AGCTTCGTGCCTCGGGCTATCGGTTGATTTACCAGGTCAGAGACAACGTGGTGACGGTGTTTGTCGTGGCGATTGGTAAG
CGTGAAAAAGAGGCGGCTTACCACAGCGCCACTCACCGTCTGTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13692.44 Da        Isoelectric Point: 3.9837

>AT157448 WP_129979813.1 NZ_CP053683:1644792-1645157 [Proteus mirabilis]
MFNIRRLSLDLNSIAIVTAIGYENPLSSLSEIEHELTCLLGQELNGEVIFDLVCSNGLEWNRFLSLQVKNGSFDYNSVSI
LDKTDFISQLFDEQAYFLSNNLHYLQDSVLTSDEIPRVIGV

Download         Length: 366 bp

>AT157448 NZ_CP069319:c4340131-4339889 [Kosakonia cowanii]
ATGGCAACGCTCAATGTTCGACTGGATGACAAGCTCAAAGAGGAGGCCTGGAAAGTGCTGGAGAAACTCGACATTACGCC
CACCGAAGCGGTGCGCCTGCTGTTTCAATACGTTGCCGAGAATGGCCGCATGCCGGTTAAAACCGTAACGGTGAGCGAAG
ACGAAGCGGCACTGCTGGAGGTGGTCAGAGAGCGCCTGGCGAACCCGCAAAAAGGGATCAAGGTCAGGCTGGATGATCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References