Detailed information of TA system TA157447

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1624982..1626553
• Replicon: chromosome
• Accession: NZ_CP053683
• Organism: Proteus mirabilis strain MPE0027

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HNV02_RS07550
• Protein ID: WP_175233737.1
• Coordinates: 1624982..1626295 (-)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HNV02_RS07555
• Protein ID: WP_049203075.1
• Coordinates: 1626296..1626553 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HNV02_RS07530	1620151..1620954	+	804	WP_063073815.1	energy transducer TonB	-
HNV02_RS07535	1621008..1622969	-	1962	WP_063073816.1	hypothetical protein	-
HNV02_RS07540	1623001..1623930	-	930	WP_004246518.1	metallophosphoesterase	-
HNV02_RS07545	1624115..1624579	-	465	WP_063073817.1	DUF1097 domain-containing protein	-
HNV02_RS07550	1624982..1626295	-	1314	WP_175233737.1	type II toxin-antitoxin system HipA family toxin	Toxin
HNV02_RS07555	1626296..1626553	-	258	WP_049203075.1	helix-turn-helix domain-containing protein	Antitoxin
HNV02_RS07560	1626998..1627840	+	843	WP_001965929.1	hypothetical protein	-
HNV02_RS07565	1627837..1628268	+	432	WP_119298318.1	hypothetical protein	-
HNV02_RS07570	1628394..1628843	+	450	WP_148497122.1	hypothetical protein	-
HNV02_RS07575	1628977..1629603	+	627	WP_175233738.1	recombinase family protein	-
HNV02_RS07580	1629790..1630005	+	216	WP_110775826.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49648.73 Da
• Isoelectric Point: 6.2444

>T157447 WP_175233737.1 NZ_CP053683:c1626295-1624982 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNDWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Nucleotide

• Length: 1314 bp

>T157447 NZ_CP069319:c4205585-4205280 [Kosakonia cowanii]
ATGGGAAAGAGTAAACGCGCGCGCCTGCCATTCCGCTCCGATTACACCAAAACCTTTGTGAAGGCCTGGGAGCGATATAA
CAAAGCGGGACGCCGGGACATGCATGAGACGGCTGCTATCATGTCGATGGTGCTCTCCGGCAACCCGCTTCCCGCTCAAT
ATAACGATCATGCTTTAACCGGAAATATGCAGGGGTTTCGCGAGCTGCATATTGGCGGTGACTATCTGCTGGTATATCGC
CTTGATGGCGAAAAGCATCTGGTGGTATTCACCGATTTGGGCACCCATGCCGAGCTATTCGAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT157447 WP_049203075.1 NZ_CP053683:c1626553-1626296 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFEINPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT157447 NZ_CP069319:c4205844-4205572 [Kosakonia cowanii]
ATGGATTCTGTTATCCGATCGCGTATCGACAGCGAACTCAAGGCACGCGCCGGGCTGGTGCTTGAAAATTGCGGCCTCAA
CTGGAGCACGGCGATACGCCTGTTTGCTGAGCAAATTGTTAAAAACGAAGGGATACCTTTTGAAATCACCGCGAAACCAA
CCGCCCGGTTACGTAACGCAATGGTTGAGGCCGAAGAGATCGCCGCGCAAAAGCAGGGACGCTTTGAGAGTGTTGAACAG
CTAATGGACAGCTTAAACGATGGGAAAGAGTAA