Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 869693..871415 Replicon chromosome
Accession NZ_CP053683
Organism Proteus mirabilis strain MPE0027

Toxin (Protein)


Gene name mosT Uniprot ID A0A229ALQ0
Locus tag HNV02_RS04065 Protein ID WP_052921265.1
Coordinates 869693..870631 (-) Length 313 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A229AKX4
Locus tag HNV02_RS04070 Protein ID WP_052921266.1
Coordinates 870624..871415 (-) Length 264 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HNV02_RS04045 865007..867406 - 2400 WP_052921263.1 type IV secretion system protein TraC -
HNV02_RS04050 867406..868098 - 693 WP_024008832.1 DsbC family protein -
HNV02_RS04055 868340..868486 + 147 WP_162869655.1 hypothetical protein -
HNV02_RS04060 868530..869186 + 657 WP_052921264.1 hypothetical protein -
HNV02_RS04065 869693..870631 - 939 WP_052921265.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
HNV02_RS04070 870624..871415 - 792 WP_052921266.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
HNV02_RS04075 871635..872021 - 387 WP_000180225.1 hypothetical protein -
HNV02_RS04080 872018..872590 - 573 WP_024008834.1 type IV conjugative transfer system lipoprotein TraV -
HNV02_RS04085 872665..873954 - 1290 WP_052921268.1 TraB/VirB10 family protein -
HNV02_RS04090 873957..874853 - 897 WP_175233795.1 type-F conjugative transfer system secretin TraK -
HNV02_RS04095 874837..875463 - 627 WP_000667170.1 hypothetical protein -
HNV02_RS04100 875460..875741 - 282 WP_000433889.1 type IV conjugative transfer system protein TraL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(J) - 773079..938747 165668


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(99-250)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 35487.78 Da        Isoelectric Point: 5.1093

>T157445 WP_052921265.1 NZ_CP053683:c870631-869693 [Proteus mirabilis]
MDKGSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALVNVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSLVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLTSLQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNIYKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Download         Length: 939 bp

>T157445 NZ_CP069319:2025324-2025426 [Kosakonia cowanii]
GCAAGGCGACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 264 a.a.        Molecular weight: 30113.48 Da        Isoelectric Point: 9.5097

>AT157445 WP_052921266.1 NZ_CP053683:c871415-870624 [Proteus mirabilis]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLELNPEKDLKRITVKEKELTVSCAELAAY
EVVDGIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWINRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Download         Length: 792 bp

>AT157445 NZ_CP069319:c2025428-2025264 [Kosakonia cowanii]
ATAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTTAGTCGCCTTGCACCTTAAGAATAGATGACGACACCAGCTTTTCCAGTCCGCGACAAATGTGGTCAG
AAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A229ALQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A229AKX4

References