Detailed information of TA system TA157443

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2330837..2331482
• Replicon: chromosome
• Accession: NZ_CP053682
• Organism: Proteus mirabilis strain MPE0156

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HNS39_RS10415
• Protein ID: WP_060557166.1
• Coordinates: 2331297..2331482 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B4ET85
• Locus tag: HNS39_RS10410
• Protein ID: WP_004247034.1
• Coordinates: 2330837..2331250 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HNS39_RS10380	2326595..2327089	+	495	WP_060557147.1	hypothetical protein	-
HNS39_RS10385	2327378..2327536	-	159	WP_004247025.1	hypothetical protein	-
HNS39_RS10390	2327985..2328161	+	177	WP_004247793.1	hypothetical protein	-
HNS39_RS10395	2328338..2329084	-	747	WP_060557148.1	class I SAM-dependent methyltransferase	-
HNS39_RS10400	2329951..2330529	+	579	WP_060557149.1	alpha/beta hydrolase	-
HNS39_RS10405	2330636..2330794	+	159	Protein_2009	terminase	-
HNS39_RS10410	2330837..2331250	-	414	WP_004247034.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HNS39_RS10415	2331297..2331482	-	186	WP_060557166.1	type II toxin-antitoxin system HicA family toxin	Toxin
HNS39_RS10420	2332325..2333911	+	1587	WP_060557150.1	hypothetical protein	-
HNS39_RS10425	2334149..2335324	-	1176	WP_060557151.1	site-specific integrase	-
HNS39_RS10430	2335326..2335538	-	213	WP_020945460.1	hypothetical protein	-
HNS39_RS10435	2335953..2336123	-	171	WP_020945461.1	hypothetical protein	-
HNS39_RS10440	2336151..2336330	-	180	WP_004250516.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2326595..2384067	57472

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7034.29 Da
• Isoelectric Point: 11.1504

>T157443 WP_060557166.1 NZ_CP053682:c2331482-2331297 [Proteus mirabilis]
MKSSELIKLLEKNGWVLDRIKGSHHQFTHPNFSFVVTVPHPRKDLKKGTLNQILKSAKLKN

Nucleotide

• Length: 186 bp

>T157443 NZ_CP069319:c664664-664383 [Kosakonia cowanii]
ATGACCTATAAGCTGGCGTTCAACGTATCGGCATTAAAGGAGTGGAAGAAGCTGGGAAGCACCGTTCGCGAGCAGTTCAA
AAAGAAGCTTCAGGAGCGGCTCGAAAACCCGCGCGTCCCGGCAGCACAGCTCAATGGGCGCAAAGATCAGTACAAAATTA
AGCTACGCGGTGCGGGATACCGGCTGGTCTATAAAGTCGAAGAGGAGATCATCACCGTGACGGTGATCGGTGTGGGCAAA
CGCGAGAACGATGAGATCTATACAGCCACACGCTTCAGGTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15251.98 Da
• Isoelectric Point: 4.3830

>AT157443 WP_004247034.1 NZ_CP053682:c2331250-2330837 [Proteus mirabilis]
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI

Nucleotide

• Length: 414 bp

>AT157443 NZ_CP069319:c664902-664654 [Kosakonia cowanii]
ATGCCATTCCAGATTCTGACGACCACCGCAGCCAGCATCACCGAACTGAAACGTGACCCGATGGGGACATTTAATGCCGG
GGAAGGCGCGCCGGTTGCCATTCTTAATCGCAATGAACCCGCGTTCTACTGCGTCCCGCCCGCGCTCTATGCACGCCTGA
TGGAGCTGCTTGAAGACGAAGAGCTGGGGCGCATTGCGGACGAGCGTGCTGATGAACCCACCATCGAGGTCAAGCTTGAT
GACCTATAA

Structures

Antitoxin

• AlphaFold DB: B4ET85