Detailed information of TA system TA157441

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 191761..193490
• Replicon: chromosome
• Accession: NZ_CP053682
• Organism: Proteus mirabilis strain MPE0156

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HNS39_RS00815
• Protein ID: WP_060556490.1
• Coordinates: 191761..193131 (+)
• Length: 457 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HNS39_RS00820
• Protein ID: WP_060556489.1
• Coordinates: 193128..193490 (+)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HNS39_RS00800	187422..188405	-	984	WP_060556493.1	ABC transporter permease	-
HNS39_RS00805	188390..189973	-	1584	WP_060556492.1	ABC transporter substrate-binding protein	-
HNS39_RS00810	190374..191366	-	993	WP_060556491.1	glycosyltransferase	-
HNS39_RS00815	191761..193131	+	1371	WP_060556490.1	type II toxin-antitoxin system HipA family toxin	Toxin
HNS39_RS00820	193128..193490	+	363	WP_060556489.1	helix-turn-helix domain-containing protein	Antitoxin
HNS39_RS00825	193630..194118	-	489	WP_071524522.1	hydrogenase maturation peptidase HycI	-
HNS39_RS00830	194127..194537	-	411	WP_004245685.1	formate hydrogenlyase maturation HycH family protein	-
HNS39_RS00835	194530..195312	-	783	WP_060556488.1	NADH-quinone oxidoreductase subunit B family protein	-
HNS39_RS00840	195309..195863	-	555	WP_004245688.1	hydrogenase 4 subunit H	-
HNS39_RS00845	195875..197608	-	1734	WP_060556487.1	hydrogenase large subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (174-415)

Antitoxin

• Cro/C1-type helix-turn-helix domain (46-101)

Sequences

Toxin

Protein

• Length: 457 a.a.
• Molecular weight: 52482.38 Da
• Isoelectric Point: 4.7776

>T157441 WP_060556490.1 NZ_CP053682:191761-193131 [Proteus mirabilis]
MEKITLQAFLNQEWRDIAIINFPNDGHLALENQYDITYPITELAYESDYSIDYLFRDDHHAVSLNHPVSLFFDDKGSPGW
FKFLDDIVPSGASRRYWVQYLDIAGLSIAQQNYQLLRNGTISPIGNLRVKESLPHLSTLNNDLFFTIDEVKNRSSDFLEY
AQRKGAAAGGATGAGGEAPKLLLRCSHDEKIWIDTYQNDISNHDRYYLVKFPRGRRTSVDCNILRTEYAFYHELTAMGFN
TIPIEGMRLEEGDNYPSLWLPRFDIQIENNQVIRLAMESVYSILNKASGTTLYHEAVIREIIEKINQSNMVTEFGFQFNI
TNFIIEWVRRDLLNIIFGNSDNHGRNTSFIRKDNAIYLAPIYDFAPMKADPEGIVRTTKWQSYEMGGEFDFIGIANSLAD
LIPQEQLLEALRETALQLLDLKERLKERGVPEQILTMPTFGFDFIPDKLARWGLLP

Nucleotide

• Length: 1371 bp

>T157441 NZ_CP069319:c49411-49106 [Kosakonia cowanii]
ATGGAGAAAGGAACTCCCCATGTCCGCTTACATATCGTCAAGCGGATGGTGCTTGAGGGAAAGGTCAGAACCACGGCCAG
CGCTGTCGCGGGAGCGATTGAATTAGGCTTTAATCCACCGCCATTTGACGAGATGTGCGCAGTAATTCAGGCGCTCACTT
CAGAAGATTTTTTTAAAAGCATGACGGCATATGTCGATCATACGGTGTGGCACGATGTTTACCGGCCAGTCTGGAAGAGG
CAAAAACTTTATCTAAAGTTAATCGTCTCTGACGATGTACTGATCGTGTCATTTAAGGAGAGATAA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13542.07 Da
• Isoelectric Point: 10.6882

>AT157441 WP_060556489.1 NZ_CP053682:193128-193490 [Proteus mirabilis]
MNNIDNKITKLPLRASNNRSLIATIDRKKTIEKIMLSLLLEEISQGKALKILRLNILGLKQDAYAKLVNISRKTLSDIEN
DKGNYSIDIINKAFKPFGLKIGLVPATSHMLLSILKNHYQ

Nucleotide

• Length: 363 bp

>AT157441 NZ_CP069319:c49105-48704 [Kosakonia cowanii]
ATGAAATGCCCTGTTTGCGGCGCTGCGGGACTCAAACATGACACCCGCAACATTGAATACCGTTACAAAGGGAAAGTGAC
TACGCTCACTGCGATCACAGGCGATTACTGCGACGCATGTGGAGAGATCATTTTTGACCGTCTGAACGGTGAACTTTACT
CAAAACAGGTTGCGGCTTTTGTCCGCAAAGTTAACGCAGAAGAGGTTGATCCTCAGTTTATTGCCACTATCCGAAAGCGG
TTTAATCTCGATCAGCGCCAGGCAGCAGAGATGTTTGGCGGTGGCGCAAACGCCTTTAGCCGGTACGAAACCGGACGTGT
TGCACCGCCAAGACCTTTAGTTTTGCTCTTTAAGGCGCTGGACAAGCATCCAGAGCTTTTCGAGGAGCTAAAACATGCCT
GA