157440

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 36149..37170 Replicon chromosome
Accession NZ_CP053682
Organism Proteus mirabilis strain MPE0156

Toxin (Protein)


Gene name PP_4152 Uniprot ID A0A8E4FRK4
Locus tag HNS39_RS00160 Protein ID WP_017827532.1
Coordinates 36601..37170 (+) Length 190 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID B4F2H3
Locus tag HNS39_RS00155 Protein ID WP_004245528.1
Coordinates 36149..36601 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HNS39_RS00135 31935..32465 - 531 WP_004245524.1 RNA pyrophosphohydrolase -
HNS39_RS00140 32734..33747 + 1014 WP_107033621.1 thiamine ABC transporter substrate binding subunit -
HNS39_RS00145 33747..35327 + 1581 WP_060557657.1 thiamine/thiamine pyrophosphate ABC transporter permease ThiP -
HNS39_RS00150 35320..36021 + 702 WP_004245527.1 thiamine ABC transporter ATP-binding protein ThiQ -
HNS39_RS00155 36149..36601 + 453 WP_004245528.1 helix-turn-helix domain-containing protein Antitoxin
HNS39_RS00160 36601..37170 + 570 WP_017827532.1 PIN domain-containing protein Toxin
HNS39_RS00165 37286..39640 + 2355 WP_060557656.1 DNA polymerase II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-113)

Antitoxin

SinI-like, DNA-binding domain

(80-125)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21601.08 Da        Isoelectric Point: 7.0180

>T157440 WP_017827532.1 NZ_CP053682:36601-37170 [Proteus mirabilis]
MTNYTVLLDACVMYPAPLRSYLMYLANTGLFRARWSNQIHDEWITNLLVNNPTLTAERLIRTRDLMNAHVPDCLVEGYEP
LICGLKLPDPNDRHVLAAAIKGQAQAIITFNLKDFPQKYLNSFDISAIHPDEFLSDMFELNPSSCIKAAQQHRQSLKDPP
MTVETFLGCLQKQKLPQFISHLRAFQILL

Download         Length: 570 bp

>T157440 NZ_CP069318:c6493474-6492620 [Delftia lacustris]
ATGACCCCCTCGGTAACAGCATGCATGGAGCAGCGCCTTCAGGCGCAGTTCCCCGAACATCTCATCGCCCTGCCCGGGGG
CGCCCAGGTCGCCTGGCGCGAGGCCGGCGACACGGCCTCGGACTTTGCCGTGGTGATGCTGCACGGCATCAGCTCGGGCG
CCGCCTCCTGGCTGGACGTGGCCCTGGCGCTGGCGCCGCGCACGCGTGTGCTGGCCTGGGACGCGCCCGGCTATGGCCGC
TCCACACCGCTGGCACCCGCCGCGCCCACGGGCGCCGACTACGCCCGCGTGCTGGAGCAGTCGCTGCAGGCGCTGGGCGT
GCGCCGCTGCCTGCTGGTGGGTCACTCGCTGGGTGCGCTCATGGGCACGCCCTGGGCGGTGCAGGCCGGTGCCGGGCGCG
TGCAGCAACTGGTGCTGATCAGCCCCGCTGGCGGCTATGGCGCACCCGGCATGGGCGAGCAGCAGGCCAAGGTACGCCAG
GGCCGTCTTGCGGCCCTGCAGGAAAAAGGCATCGAAGGCCTGGCCGCCGCCATCGACCAGCGCCTGGTCTCGCCCGCCGC
GCCCGAGCCCGTGCGCCAATGGGTGCGCTGGAACACGGCGCGCCTGCATGCCGCAGGCTACGCCCAGGCCGTGGAACTGC
TGTGCGGCAGCGACCTGGGGCAGGCGGCGGGGCGCCTTGCCATGCCGGTCGAGGTCTGGGTGGGAGAGCACGACGTGGTC
ACGCCGCCGGCTGCCTGCGCGGCCTGGGCCGCAAGACTGGGGGCGCGGTACGTTACGCTTGCGGCAGCCGGCCATGCCTC
TGTCGTCGAACAACCTGCGGATGTCGCACAGAGGCTGGCCACCCTGCTGACCTGA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16700.15 Da        Isoelectric Point: 5.7723

>AT157440 WP_004245528.1 NZ_CP053682:36149-36601 [Proteus mirabilis]
MNTISERLSAEDIALAKLSSQELSAVMDINGKTQKLSIIDKTGNNHIVQIPNSALRLMIEILTQLGQGNTVSITPIHAEL
TTQEAADILNMSRPTFVKLLDTRAIPYSRKGNRRKVAYADIVAYKNELEQKRLDALAELSQLDQEMDMGY

Download         Length: 453 bp

>AT157440 NZ_CP069318:c6492597-6491791 [Delftia lacustris]
ATGAGCGATACCTCCGAAACCCTCTCGAACGACAACGACCGCTACACCGTCCCCGCGCTGGAGCGCGGCCTGCGCCTGCT
GGCCTGCTTCACGCCTTCGCAGCCCGTGTGGAGCGCGCCCGACCTGGCGCGCACCCTGGCGCTGCCCCGGTCCACGGTGT
TCCGGATGCTGACGACGCTGGAGGGCATGGGGTATCTGCAACGCTCGGGCACCGAATACCGGCTGGGCCTGGCCGTGCTG
CGCCTGGGCTACGACTACCTGTCCACCCAGCCGCTGGCCCAGCTGGCCGAGCCCGTGCTGCAGTCGCTGTGCGACCGGCT
GGGCTTCACCACCAACCTGGCGCTGCTGGACGGCACCTCGGTGGTCTATGTGGCGCGCATCGCGCCGGCCGGCGCCTTCC
AGGGCGCCGTGCGCGTGGGCTCGCGGCTGCCGGCCCATGCCACCGTGCTGGGCCGGGCACTGCTGCAGGACATGGACGCG
GACCAGCTGCGCGCCCTGTTCGGCGGCAGCGAACTGCCCCAGTTCTCGGAAAGCACGCCGCGCAGCGTGGAACAGTTGCT
GCAGTTGCTGCAGCAGGACCATGAACGCGGCTACGCCATGGGCGAGGGCTTCTACGAGCCCGGCGTCTCCAGCATCGCCG
CGCCCGTGCGCGATGCGCAGGGGCGCATCGTGGCGGGCCTGGGCATGGCCGTGGCCTTCACCGAAATCGCTCCCGGCCGC
ATGGCCGACTGGGTGGAGCAGGTGCGTGCCGCCGCCGATGAGCTGGCCGGCCACCTGCGCACCCAGCATCCCGGTTTTCT
GCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4F2H3

References