Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 3547799..3548444 | Replicon | chromosome |
Accession | NZ_CP053681 | ||
Organism | Proteus mirabilis strain M3-1-17 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | - |
Locus tag | HNS37_RS16040 | Protein ID | WP_060557166.1 |
Coordinates | 3548259..3548444 (-) | Length | 62 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | B4ET85 |
Locus tag | HNS37_RS16035 | Protein ID | WP_004247034.1 |
Coordinates | 3547799..3548212 (-) | Length | 138 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HNS37_RS16005 | 3543557..3544051 | + | 495 | WP_060557147.1 | hypothetical protein | - |
HNS37_RS16010 | 3544340..3544498 | - | 159 | WP_004247025.1 | hypothetical protein | - |
HNS37_RS16015 | 3544947..3545123 | + | 177 | WP_004247793.1 | hypothetical protein | - |
HNS37_RS16020 | 3545300..3546046 | - | 747 | WP_060557148.1 | class I SAM-dependent methyltransferase | - |
HNS37_RS16025 | 3546913..3547491 | + | 579 | WP_060557149.1 | alpha/beta hydrolase | - |
HNS37_RS16030 | 3547598..3547756 | + | 159 | Protein_3095 | terminase | - |
HNS37_RS16035 | 3547799..3548212 | - | 414 | WP_004247034.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
HNS37_RS16040 | 3548259..3548444 | - | 186 | WP_060557166.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
HNS37_RS16045 | 3549287..3550873 | + | 1587 | WP_060557150.1 | hypothetical protein | - |
HNS37_RS16050 | 3551111..3552286 | - | 1176 | WP_060557151.1 | site-specific integrase | - |
HNS37_RS16055 | 3552288..3552500 | - | 213 | WP_020945460.1 | hypothetical protein | - |
HNS37_RS16060 | 3552915..3553085 | - | 171 | WP_020945461.1 | hypothetical protein | - |
HNS37_RS16065 | 3553113..3553292 | - | 180 | WP_004250516.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 3538896..3601029 | 62133 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 62 a.a. Molecular weight: 7034.29 Da Isoelectric Point: 11.1504
>T157439 WP_060557166.1 NZ_CP053681:c3548444-3548259 [Proteus mirabilis]
MKSSELIKLLEKNGWVLDRIKGSHHQFTHPNFSFVVTVPHPRKDLKKGTLNQILKSAKLKN
MKSSELIKLLEKNGWVLDRIKGSHHQFTHPNFSFVVTVPHPRKDLKKGTLNQILKSAKLKN
Download Length: 186 bp
>T157439 NZ_CP069318:6184614-6184895 [Delftia lacustris]
ATGGCGATCACTTCCTTCAAGTGCCCGGAAACCCAGCGCCTGTTCACCAGCGGCAAGACCCGCCGCTTCGCCAACATCCA
GAGCGTGGCGGAGCGCAAGCTGGCTCAGCTGGATGCGGCTGTGACACTTGAATTTCTGCGCAGCCCTCCTGGCAATCGCC
TGGAAATGCTCGTGGGAGATCGGCAGGGCCAGCACAGCATCCGCATCAACGACCAGTGGCGCCTCTGCTTTGTCTGGACG
GAAAAGGGAGTGGTTGACGTAGAGATAGTGGATTACCACTGA
ATGGCGATCACTTCCTTCAAGTGCCCGGAAACCCAGCGCCTGTTCACCAGCGGCAAGACCCGCCGCTTCGCCAACATCCA
GAGCGTGGCGGAGCGCAAGCTGGCTCAGCTGGATGCGGCTGTGACACTTGAATTTCTGCGCAGCCCTCCTGGCAATCGCC
TGGAAATGCTCGTGGGAGATCGGCAGGGCCAGCACAGCATCCGCATCAACGACCAGTGGCGCCTCTGCTTTGTCTGGACG
GAAAAGGGAGTGGTTGACGTAGAGATAGTGGATTACCACTGA
Antitoxin
Download Length: 138 a.a. Molecular weight: 15251.98 Da Isoelectric Point: 4.3830
>AT157439 WP_004247034.1 NZ_CP053681:c3548212-3547799 [Proteus mirabilis]
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI
Download Length: 414 bp
>AT157439 NZ_CP069318:6184977-6185288 [Delftia lacustris]
ATGCTTAAAAACGGCATGCGCCCCATACACCCAGGTGAAGTCCTGCGCGAGGACTACCTGAAGCCCATGGACATGAGCGC
CAACGCGCTGGCCAGGCACCTGCACGTTCCCGCCTCGCGCGTGAACGACATCGTGCTGGAGCGGCGCGGCATCACGGCCG
ACACGGCGCTGCGGCTGAGCCGCTTCTTTGGGGGCGACGCGCAGTCCTGGCTGAACCTTCAGACCGCCTACGACCTGCGC
ACGGCAGAGCTGAACGCGGAGTTGCAGGCGTCCGTGAGGCAAGTTCATCCGATGCAGCTGCATACCGCCTGA
ATGCTTAAAAACGGCATGCGCCCCATACACCCAGGTGAAGTCCTGCGCGAGGACTACCTGAAGCCCATGGACATGAGCGC
CAACGCGCTGGCCAGGCACCTGCACGTTCCCGCCTCGCGCGTGAACGACATCGTGCTGGAGCGGCGCGGCATCACGGCCG
ACACGGCGCTGCGGCTGAGCCGCTTCTTTGGGGGCGACGCGCAGTCCTGGCTGAACCTTCAGACCGCCTACGACCTGCGC
ACGGCAGAGCTGAACGCGGAGTTGCAGGCGTCCGTGAGGCAAGTTCATCCGATGCAGCTGCATACCGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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