Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3547799..3548444 Replicon chromosome
Accession NZ_CP053681
Organism Proteus mirabilis strain M3-1-17

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HNS37_RS16040 Protein ID WP_060557166.1
Coordinates 3548259..3548444 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID B4ET85
Locus tag HNS37_RS16035 Protein ID WP_004247034.1
Coordinates 3547799..3548212 (-) Length 138 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HNS37_RS16005 3543557..3544051 + 495 WP_060557147.1 hypothetical protein -
HNS37_RS16010 3544340..3544498 - 159 WP_004247025.1 hypothetical protein -
HNS37_RS16015 3544947..3545123 + 177 WP_004247793.1 hypothetical protein -
HNS37_RS16020 3545300..3546046 - 747 WP_060557148.1 class I SAM-dependent methyltransferase -
HNS37_RS16025 3546913..3547491 + 579 WP_060557149.1 alpha/beta hydrolase -
HNS37_RS16030 3547598..3547756 + 159 Protein_3095 terminase -
HNS37_RS16035 3547799..3548212 - 414 WP_004247034.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HNS37_RS16040 3548259..3548444 - 186 WP_060557166.1 type II toxin-antitoxin system HicA family toxin Toxin
HNS37_RS16045 3549287..3550873 + 1587 WP_060557150.1 hypothetical protein -
HNS37_RS16050 3551111..3552286 - 1176 WP_060557151.1 site-specific integrase -
HNS37_RS16055 3552288..3552500 - 213 WP_020945460.1 hypothetical protein -
HNS37_RS16060 3552915..3553085 - 171 WP_020945461.1 hypothetical protein -
HNS37_RS16065 3553113..3553292 - 180 WP_004250516.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3538896..3601029 62133


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 62 a.a.        Molecular weight: 7034.29 Da        Isoelectric Point: 11.1504

>T157439 WP_060557166.1 NZ_CP053681:c3548444-3548259 [Proteus mirabilis]
MKSSELIKLLEKNGWVLDRIKGSHHQFTHPNFSFVVTVPHPRKDLKKGTLNQILKSAKLKN

Download         Length: 186 bp

>T157439 NZ_CP069318:6184614-6184895 [Delftia lacustris]
ATGGCGATCACTTCCTTCAAGTGCCCGGAAACCCAGCGCCTGTTCACCAGCGGCAAGACCCGCCGCTTCGCCAACATCCA
GAGCGTGGCGGAGCGCAAGCTGGCTCAGCTGGATGCGGCTGTGACACTTGAATTTCTGCGCAGCCCTCCTGGCAATCGCC
TGGAAATGCTCGTGGGAGATCGGCAGGGCCAGCACAGCATCCGCATCAACGACCAGTGGCGCCTCTGCTTTGTCTGGACG
GAAAAGGGAGTGGTTGACGTAGAGATAGTGGATTACCACTGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15251.98 Da        Isoelectric Point: 4.3830

>AT157439 WP_004247034.1 NZ_CP053681:c3548212-3547799 [Proteus mirabilis]
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI

Download         Length: 414 bp

>AT157439 NZ_CP069318:6184977-6185288 [Delftia lacustris]
ATGCTTAAAAACGGCATGCGCCCCATACACCCAGGTGAAGTCCTGCGCGAGGACTACCTGAAGCCCATGGACATGAGCGC
CAACGCGCTGGCCAGGCACCTGCACGTTCCCGCCTCGCGCGTGAACGACATCGTGCTGGAGCGGCGCGGCATCACGGCCG
ACACGGCGCTGCGGCTGAGCCGCTTCTTTGGGGGCGACGCGCAGTCCTGGCTGAACCTTCAGACCGCCTACGACCTGCGC
ACGGCAGAGCTGAACGCGGAGTTGCAGGCGTCCGTGAGGCAAGTTCATCCGATGCAGCTGCATACCGCCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB B4ET85

References