Detailed information of TA system TA157437

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1408692..1410421
• Replicon: chromosome
• Accession: NZ_CP053681
• Organism: Proteus mirabilis strain M3-1-17

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HNS37_RS06440
• Protein ID: WP_060556490.1
• Coordinates: 1408692..1410062 (+)
• Length: 457 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HNS37_RS06445
• Protein ID: WP_060556489.1
• Coordinates: 1410059..1410421 (+)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HNS37_RS06425	1404353..1405336	-	984	WP_060556493.1	ABC transporter permease	-
HNS37_RS06430	1405321..1406904	-	1584	WP_060556492.1	ABC transporter substrate-binding protein	-
HNS37_RS06435	1407305..1408297	-	993	WP_060556491.1	glycosyltransferase	-
HNS37_RS06440	1408692..1410062	+	1371	WP_060556490.1	type II toxin-antitoxin system HipA family toxin	Toxin
HNS37_RS06445	1410059..1410421	+	363	WP_060556489.1	helix-turn-helix domain-containing protein	Antitoxin
HNS37_RS06450	1410561..1411049	-	489	WP_071524522.1	hydrogenase maturation peptidase HycI	-
HNS37_RS06455	1411058..1411468	-	411	WP_004245685.1	formate hydrogenlyase maturation HycH family protein	-
HNS37_RS06460	1411461..1412243	-	783	WP_060556488.1	NADH-quinone oxidoreductase subunit B family protein	-
HNS37_RS06465	1412240..1412794	-	555	WP_004245688.1	hydrogenase 4 subunit H	-
HNS37_RS06470	1412806..1414539	-	1734	WP_060556487.1	hydrogenase large subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (174-415)

Antitoxin

• Cro/C1-type helix-turn-helix domain (46-101)

Sequences

Toxin

Protein

• Length: 457 a.a.
• Molecular weight: 52482.38 Da
• Isoelectric Point: 4.7776

>T157437 WP_060556490.1 NZ_CP053681:1408692-1410062 [Proteus mirabilis]
MEKITLQAFLNQEWRDIAIINFPNDGHLALENQYDITYPITELAYESDYSIDYLFRDDHHAVSLNHPVSLFFDDKGSPGW
FKFLDDIVPSGASRRYWVQYLDIAGLSIAQQNYQLLRNGTISPIGNLRVKESLPHLSTLNNDLFFTIDEVKNRSSDFLEY
AQRKGAAAGGATGAGGEAPKLLLRCSHDEKIWIDTYQNDISNHDRYYLVKFPRGRRTSVDCNILRTEYAFYHELTAMGFN
TIPIEGMRLEEGDNYPSLWLPRFDIQIENNQVIRLAMESVYSILNKASGTTLYHEAVIREIIEKINQSNMVTEFGFQFNI
TNFIIEWVRRDLLNIIFGNSDNHGRNTSFIRKDNAIYLAPIYDFAPMKADPEGIVRTTKWQSYEMGGEFDFIGIANSLAD
LIPQEQLLEALRETALQLLDLKERLKERGVPEQILTMPTFGFDFIPDKLARWGLLP

Nucleotide

• Length: 1371 bp

>T157437 NZ_CP069318:c2684630-2684184 [Delftia lacustris]
ATGACACGCTACCTGCTGGACACCAACATCGCCAGCCACATCATCAAAGGCGATATCCCTGCCGTGCGCGAACAGCTGGT
TCGCGTACCCATGCACCAGATCGCAGTGTCGGCGGTCACGCAGGCCGAACTGATGTACGGGGTCGCCAAGCGCGGCCACC
CTGCCGGGCTGTCGCTGCGGGTGACAGGATTCCTGGCCCGCGTCGAGGTGCTGCCCTGGACGGCCCAGGTGGCCGATGCC
TACGGCCACCTGCGCGCCGCCTGCGAGGCGACCGGCATCACGCTGGCCTCCATGGACATGATGATTGCCGCGCACGCCCT
GCTCCTGCAGCAGCAGGCCGCGCAGGCCGGCGAGCGCTCGGTACTGGTCACAAGAGACCGGGTGTTCAGCCGCATTCCCG
AACCCGGACTGGCCATCGCGGACTGGACGACCGGCCCGGCTGGCTGA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13542.07 Da
• Isoelectric Point: 10.6882

>AT157437 WP_060556489.1 NZ_CP053681:1410059-1410421 [Proteus mirabilis]
MNNIDNKITKLPLRASNNRSLIATIDRKKTIEKIMLSLLLEEISQGKALKILRLNILGLKQDAYAKLVNISRKTLSDIEN
DKGNYSIDIINKAFKPFGLKIGLVPATSHMLLSILKNHYQ

Nucleotide

• Length: 363 bp

>AT157437 NZ_CP069318:c2684893-2684627 [Delftia lacustris]
GTGACGCAGACTGCCAAGCTTTTCACCACCGGTCGCAGCCAGGCCGTGCGCCTTCCCTATGAATTCCGGTTCGAGGAAAA
AGAGGTCTACATACGTCGCGACCCCGCCACGGGCGACGTGATCCTGTCGCGCCGTCCCGACTCATGGCAAGAGTTCTTTG
CGCTCGACGCCACCACCGACGTGCCGGCCGATTTCATGGACACCGCTGACCGAGCGCAGCCAGAGTCAGGCCGCGATCCG
TTTGCCGACGAAGGCAGTGCGCGATGA