Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2317775..2318361 Replicon chromosome
Accession NZ_CP053676
Organism MAG: Ferrovum myxofaciens isolate S2.4

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HO274_RS11430 Protein ID WP_273119785.1
Coordinates 2318017..2318361 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HO274_RS11425 Protein ID WP_273119783.1
Coordinates 2317775..2318017 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO274_RS11395 (HO274_11360) 2313129..2313416 + 288 WP_273119772.1 hypothetical protein -
HO274_RS11400 (HO274_11365) 2313901..2314134 - 234 WP_273119774.1 antitoxin of toxin-antitoxin stability system -
HO274_RS11405 (HO274_11370) 2314204..2315271 + 1068 WP_273119777.1 IS1595 family transposase -
HO274_RS11410 (HO274_11375) 2315382..2315957 - 576 WP_273119779.1 thioredoxin family protein -
HO274_RS11415 (HO274_11385) 2316202..2317272 - 1071 WP_273119781.1 IS630 family transposase -
HO274_RS11420 (HO274_11390) 2317463..2317627 + 165 Protein_2237 transposase domain-containing protein -
HO274_RS11425 (HO274_11395) 2317775..2318017 + 243 WP_273119783.1 hypothetical protein Antitoxin
HO274_RS11430 (HO274_11400) 2318017..2318361 + 345 WP_273119785.1 endoribonuclease MazF Toxin
HO274_RS11435 (HO274_11405) 2318410..2318928 - 519 WP_273119786.1 transposase -
HO274_RS11440 (HO274_11415) 2319117..2319389 + 273 WP_273119788.1 DUF1778 domain-containing protein -
HO274_RS11445 (HO274_11420) 2319386..2319880 + 495 WP_273119791.1 GNAT family N-acetyltransferase -
HO274_RS11450 (HO274_11425) 2320003..2321310 + 1308 WP_273119793.1 RecQ family ATP-dependent DNA helicase -
HO274_RS11455 (HO274_11430) 2321228..2321827 - 600 WP_273119795.1 hypothetical protein -
HO274_RS11460 (HO274_11435) 2321824..2322114 - 291 WP_273119797.1 nucleotidyltransferase domain-containing protein -
HO274_RS11465 (HO274_11440) 2322176..2323324 - 1149 WP_273119799.1 glycosyltransferase family 87 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2106482..2343663 237181
- flank IS/Tn - - 2316202..2317272 1070


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(12-110)

Antitoxin

Antitoxin PemI-like

(1-80)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12507.72 Da        Isoelectric Point: 9.2272

>T157433 WP_273119785.1 NZ_CP053676:2318017-2318361 [Ferrovum myxofaciens]
MAARGYVPDASDVVWLEFDPQAGHEQAGHRPALVISPANYNSKTGLMVCCPITTKIKGHPFEVVTQVDGVDCAVLSDQVK
SLDWKVRRAKKKAVVPPEVMIHVRAKMKALLMIT

Download         Length: 345 bp

>T157433 NZ_CP069308:c1943739-1942423 [Glaesserella parasuis]
ATGGTAATGCGATTACGAGTATTAATGAATGGCGAAATGGTTGGGTATTTTGACCGCACTTTATCGGGTTCCCATCATTT
TACCTATGCTGAAAGTTGGCTAAATTCCCCATTAGCTCGCCCGATTTCCCTTTCTATGCCCCTGCAAAGAGCAACATATC
AAGGCAAAGAAGTGATTAATTTCTTTGATAATTTACTGCCCGATAATCCTCAAATTCGAGCAAGAATTGCGACAAGATTT
AATGCTGAAACACAACAACCTTTTGACTTACTTGCTAAAATTGGTCGCGATGCTGCGGGTGCTATTACTCTTTTAGGGGA
AGATGAACAAATTCCTAATCATCGAATAATTCAAGCCACAGAATTAGACGAAAGTGAAATGACGAAAATTCTACAAAGTT
ATCAATACAATGCCCCGCTTGGTATGATTGATAATAATCAAGACTTCAGAATTTCTATTGCTGGTGCACAAGAAAAGACA
GCTCTGCTTTGGCATAACGGCAAATGGAAATTACCACACGGATTGACCCCGACAACGCATATTTTCAAATTGCCTATGGG
AGAAATTCGTACCCCTAAACACCTGCTTGATCTGTCAAAAAGTGTAGATAACGAACTCGTCTGTTTGAGATTATTTTCTG
CTTTCAATATCCCTTCCGCAAACGTTGAATTATTGGAAATGAACGATATACGGGCATTAGCTGTTGAACGTTTTGATCGC
CGTCTTAGTCAAGATGGCAGTTATTTTTTACGTTTACCTTACGAAGATTTCTGTCAGGCATTCGGCTTATCGCCAACGCA
AAAATATGAAAGCGATGGTGGAATTGGTATTGGGGATATGATGAATAAGTTGCTCTACTCCAGTAATTCCAACGATCGCC
GTCAATTTATGCAAACTCAATTTCTGTTTTGGCTACTGGCTGCCATTGATGGACACGCTAAAAACTTTTCTCTCGCCATT
GAAAAACAAGGGCGTTATCACTTATCCCCAGTGTATGACGTACTTTCTTCTTATCCAATGTTAGGCGGAAAAGGTTGGCA
TCACAGTGAATTACAAATGGCAATGAGCTTGCGTAGTACACAAAAAGGGAAAAAATGGCATTGGAATAAAATTTACGCTG
AACATTTCTATGCCACAGCTAAGTTTGTCGGATTTAGCTCAAGTGATATGAAACAAGTGATAGAGCAAATTTGCGATACA
GTGCAAGAAACCATTGATAGCGTAGCAACAACACTACCCAAACAGATAGATGAAAATGTACGGGATCAAATATTCACGGG
CATAATGAAACAGGTGCAAAAAGTTTCTATGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8672.05 Da        Isoelectric Point: 9.6584

>AT157433 WP_273119783.1 NZ_CP053676:2317775-2318017 [Ferrovum myxofaciens]
MEAVIRKWGNSPALRLPTSALKEAGYHLEQKVDLIVSRGRIIIQPLKKVEYDLDALVGGVTASNGHSEFGFGKPVGKEAL

Download         Length: 243 bp

>AT157433 NZ_CP069308:c1943972-1943733 [Glaesserella parasuis]
ATGTTAATCACGACACCAGATATGCTTGGAAATAGCCTACGCGATATTCGTAAGCAAAAAAAGCTTTCTCAAATGCAAAT
AGCAAATCAAGTAGCTTTAAGACAAGCCACGATTTCCACCTTTGAGAAAAAAACCGATAAAGCCACTATTGAAACATTAT
TCAAGTTACTTTCAGGTTTAGGCTATGAACTACATATCCAACCTCGTCCTGAAAAAACAGAGGGGAATGATGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References