Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2240233..2240888 Replicon chromosome
Accession NZ_CP053676
Organism MAG: Ferrovum myxofaciens isolate S2.4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HO274_RS11065 Protein ID WP_273119670.1
Coordinates 2240490..2240888 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HO274_RS11060 Protein ID WP_273119668.1
Coordinates 2240233..2240493 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO274_RS11045 (HO274_11010) 2236579..2237583 - 1005 WP_273119661.1 GNAT family N-acetyltransferase -
HO274_RS11050 (HO274_11015) 2237580..2238830 - 1251 WP_273119663.1 DegT/DnrJ/EryC1/StrS family aminotransferase -
HO274_RS11055 (HO274_11020) 2238997..2239740 - 744 WP_273119665.1 PEP-CTERM sorting domain-containing protein -
HO274_RS11060 (HO274_11025) 2240233..2240493 + 261 WP_273119668.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HO274_RS11065 (HO274_11030) 2240490..2240888 + 399 WP_273119670.1 type II toxin-antitoxin system VapC family toxin Toxin
HO274_RS11070 (HO274_11035) 2240922..2241488 + 567 WP_264753749.1 aminodeoxychorismate/anthranilate synthase component II -
HO274_RS11075 (HO274_11040) 2241454..2242254 - 801 WP_051862509.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
HO274_RS11080 (HO274_11045) 2242251..2243240 - 990 WP_273119674.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
HO274_RS11085 (HO274_11050) 2243230..2244639 - 1410 WP_082783422.1 peptidylprolyl isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2106482..2343663 237181


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(8-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14800.30 Da        Isoelectric Point: 9.6897

>T157432 WP_273119670.1 NZ_CP053676:2240490-2240888 [Ferrovum myxofaciens]
MKRYMLDTNTVRHLLKAHPTVARRMVEVPMASLSISAITEGELLFGLAKRPEAKRLHTAVREFLRRVDVLPWDSVISERY
GTVRADMEKQGNILAPLDLLIAAHALSKGAILVTNDQAFGQVANLLLEDWIN

Download         Length: 399 bp

>T157432 NZ_CP069308:1693932-1694270 [Glaesserella parasuis]
ATGAATGTCGCTTTTGTGGAGTTGCCGCCTTTTGAGGAATATAGAAAAAAGTATCTTGACGATGACTCATTTAGATTATT
ACAAAATGAGTTACTAAAATTTCCCGATAAGGGAGAGCTTATTCAAGGTACTGGGGGACTAAGAAAATTGCGTATTGTGG
ATATTATTAGACAAAAAGGAAAAAGAGGCGGAGCTAGGGTAATCTATTACTATTACGTGCGAGGGAAACAAGTTTGGTTG
TTCCACGCCTACAATAAAAACCAACAAGACGATTTATCTAATGAAGAACGTGTGGTTTTGGCGAATACATTAAGCTATTT
AAAATCTTTAGTGAGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9881.93 Da        Isoelectric Point: 4.3410

>AT157432 WP_273119668.1 NZ_CP053676:2240233-2240493 [Ferrovum myxofaciens]
MSQVAKLFLNGRSQAVRLPAAYRFDTKEVFIRQDAETGDVILSRKPTDWDSFFSALQGVDVPVDFLDAEERDQGTQNRDP
FEGWRE

Download         Length: 261 bp

>AT157432 NZ_CP069308:1694274-1694582 [Glaesserella parasuis]
ATGGGAAAATTATTTAATGAACTAATGGAAGGGATGCAAGCATTAGAGTTACACTTACAAGGCAAAATTACACTAAAAAC
CACTGTCGTGGAAGTTCCTGATCCGATAGTGATTACCCCCGAAGAAGTGAAAGCTATTCGTCAGAAATTAAATCTTTCAC
AAGCCGTTTTTGCTCGTAAATTACACACTTCGGTGAGAACTTATCAAGGCTGGGAGCAAGGAAGAACAAAACCTAATCCA
CAAGCGGTTTTATTATTAAAAATGGTTGAAAAATCACCAAAAACATTTGAGCAGATTGCGAGCATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References