Detailed information of TA system TA157431

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ParE-CopA/ParE-RHH
• Location: 2214453..2215048
• Replicon: chromosome
• Accession: NZ_CP053676
• Organism: MAG: Ferrovum myxofaciens isolate S2.4

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HO274_RS10950
• Protein ID: WP_273119626.1
• Coordinates: 2214737..2215048 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: copA
• Uniprot ID: -
• Locus tag: HO274_RS10945
• Protein ID: WP_273119625.1
• Coordinates: 2214453..2214749 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HO274_RS10915 (HO274_10885)	2209683..2210528	+	846	WP_273119616.1	hypothetical protein	-
HO274_RS10920	2210528..2210839	+	312	WP_273119617.1	ThiF family adenylyltransferase	-
HO274_RS10925 (HO274_10890)	2210785..2211387	+	603	WP_273119619.1	ThiF family adenylyltransferase	-
HO274_RS10930 (HO274_10895)	2211403..2212485	+	1083	WP_273119621.1	nitroreductase family protein	-
HO274_RS10935 (HO274_10900)	2212504..2213235	+	732	WP_051862684.1	GAF domain-containing protein	-
HO274_RS10940 (HO274_10905)	2213394..2214329	+	936	WP_273119623.1	PEP-CTERM sorting domain-containing protein	-
HO274_RS10945 (HO274_10910)	2214453..2214749	+	297	WP_273119625.1	CopG family ribbon-helix-helix protein	Antitoxin
HO274_RS10950 (HO274_10915)	2214737..2215048	+	312	WP_273119626.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HO274_RS10955 (HO274_10920)	2215183..2215512	+	330	WP_273119627.1	type II toxin-antitoxin system PrlF family antitoxin	-
HO274_RS10960 (HO274_10925)	2215509..2216021	+	513	WP_273119629.1	type II toxin-antitoxin system YhaV family toxin	-
HO274_RS10965 (HO274_10930)	2216079..2217257	-	1179	WP_273119631.1	TIGR03088 family PEP-CTERM/XrtA system glycosyltransferase	-
HO274_RS10970 (HO274_10935)	2217257..2218813	-	1557	WP_273119633.1	exosortase A	-
HO274_RS10975 (HO274_10940)	2218810..2220024	-	1215	WP_273119635.1	TIGR03087 family PEP-CTERM/XrtA system glycosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2106482..2343663	237181

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

• Ribbon-helix-helix protein, CopG (11-48)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11692.36 Da
• Isoelectric Point: 7.3137

>T157431 WP_273119626.1 NZ_CP053676:2214737-2215048 [Ferrovum myxofaciens]
MSPVIYAPGAIRDLQRLQEFLRPKNPVAARRAADTIMKAVQMLALQPQIGRPVDDHGPNEYREWLIDFGDSGYVARYHFD
GETVTILAVRHQKEAGYYQPPVV

Nucleotide

• Length: 312 bp

>T157431 NZ_CP069308:1579953-1580297 [Glaesserella parasuis]
ATGACTACTCAAGAGTATATCCCTGACGTTGGTGATATTATTTGGCTTGATTTTGATCCGCAAGCAGGACATGAACAAGC
TGGTCATCGTCCAGCATTAGTGTTAACGCCCGCGATTTATAATCGTCAAACAGGGTTGTTAATTTGCTGCCCGCTCACAA
CAAAAGTAAAAGGCTATCCTTTTGAAGTCGATATTGCAGGTACTCCTCAAAATGTTGTACTTTCCGATCAAATTAAAAGC
CTTGACTGGCGTATTCGTCACGCTAAATTTAAAGGTAAAATTAACCATCATCAGTTAAGCGAAGTAAAAGCTAAAATTGC
GACTTTGCTACAAATCAGTGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11338.64 Da
• Isoelectric Point: 5.1839

>AT157431 WP_273119625.1 NZ_CP053676:2214453-2214749 [Ferrovum myxofaciens]
MPQPHIDAKTVSVKLDADTRTRVENLAEARHRSAHWIMREAISQYVDREEKREAFRQDAIKAWEEYQETGLHATAAEVDT
WLASWGTENELPVPVCHL

Nucleotide

• Length: 297 bp

>AT157431 NZ_CP069308:1579717-1579956 [Glaesserella parasuis]
ATGCAAGTGGCTGTCAAAAAATGGGGAAATAGCGTAGGCATTCGCATTCCTGCTTTATTATCTAATTCATTGAAATTACA
GGCAGAGAGTTTAGTCGATATTCAAGAAGTTGATGGTCGCCTAATTATTGAGCCGATTAAACCTAAATATAATTTAGAGC
AACTTCTTTCGGGCATTACTGAAGATAATTTGCACAATGAAGTCGATTTTGGCAAGCCTGTTGGCAAGGAAATGCTATGA