Detailed information of TA system TA157429

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 2185510..2186119
• Replicon: chromosome
• Accession: NZ_CP053676
• Organism: MAG: Ferrovum myxofaciens isolate S2.4

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HO274_RS10770
• Protein ID: WP_273119555.1
• Coordinates: 2185510..2185686 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HO274_RS10775
• Protein ID: WP_273119560.1
• Coordinates: 2185700..2186119 (+)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HO274_RS10740 (HO274_10705)	2180737..2181798	+	1062	Protein_2101	IS66 family transposase	-
HO274_RS10745 (HO274_10710)	2181918..2182211	-	294	WP_273119544.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HO274_RS10750 (HO274_10715)	2182208..2182432	-	225	WP_273119547.1	addiction module protein	-
HO274_RS10755 (HO274_10720)	2182771..2183478	+	708	WP_273119548.1	hypothetical protein	-
HO274_RS10760 (HO274_10725)	2183757..2184089	+	333	WP_273119550.1	helix-turn-helix domain-containing protein	-
HO274_RS10765 (HO274_10730)	2184079..2185329	+	1251	WP_273119552.1	HipA domain-containing protein	-
HO274_RS10770 (HO274_10735)	2185510..2185686	+	177	WP_273119555.1	type II toxin-antitoxin system HicA family toxin	Toxin
HO274_RS10775 (HO274_10740)	2185700..2186119	+	420	WP_273119560.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HO274_RS10780 (HO274_10745)	2186238..2186432	-	195	WP_273119563.1	hypothetical protein	-
HO274_RS10785 (HO274_10750)	2186651..2187946	-	1296	WP_273119565.1	type II toxin-antitoxin system HipA family toxin	-
HO274_RS10790 (HO274_10755)	2187936..2188196	-	261	WP_273119568.1	helix-turn-helix transcriptional regulator	-
HO274_RS10795 (HO274_10760)	2188576..2190099	+	1524	WP_273119571.1	IS21 family transposase	-
HO274_RS10800 (HO274_10765)	2190111..2190884	+	774	WP_062188636.1	IS21-like element helper ATPase IstB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2106482..2343663	237181

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-58)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6335.41 Da
• Isoelectric Point: 11.0145

>T157429 WP_273119555.1 NZ_CP053676:2185510-2185686 [Ferrovum myxofaciens]
MNSKQMKKWLEQQGATFQPGKGSHLKVFLNGKQSSLPMHGTAELGKGLEAAIKRQLGL

Nucleotide

• Length: 177 bp

>T157429 NZ_CP069308:c1022118-1021840 [Glaesserella parasuis]
ATGATTATTTCATTTAAGCATAAAGGATTGAAATTATTTTTTGAAACAGGATCAACTGCAGGTATTCAGGCAAATCACGC
TAGTAAACTTGCTTTTCAATTAGCCACTCTAAACCAAGCAAAAAGTGCTTTAGATATGAATGCACCTAGCTGGAATTTAC
ATCAATTACAAGGTAATCTAGCTGGGCATTGGTCTATCAAGGTAAGTGGAAATTGGCGTTTAACTTTTAAATTTCAAAAT
GGTCACGCTGAAGTCGTGGACTATCAAGATTATCATTAA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15137.33 Da
• Isoelectric Point: 4.8989

>AT157429 WP_273119560.1 NZ_CP053676:2185700-2186119 [Ferrovum myxofaciens]
MMFDYPVTLTPDDGTMLVTFADVPEAITFGADEDEALLNAIDALETGLSFYVDARKSLPVASQPAAGQKTVRPSALECAK
LGVYQAMTDQGIKKAELARRLGWHMPQVDRLFDLRHASKLDQIEAAANVLGKHVHVQIA

Nucleotide

• Length: 420 bp

>AT157429 NZ_CP069308:c1021829-1021557 [Glaesserella parasuis]
ATGAAAATGTACAATCCAGCTCACCCAGGGCTTATTTTAAGAGAATATATTGAAGGATATAATGTCACAGAAGTGGCTAA
ACGTTTAGGTGTCACTCGTGTCACGCTTTCTCGTATTTTAAATGGCAAAGCTGCAATTTCACCTGAAATGGCTCTTAGAT
TAAGCCAATTATTAAAAACTAGCCCAGAATTATGGCTTGGTTTACAATCCCAATACGATCTTTGGCAGCTTGAACAACGC
CCAAGTTTTAATATTCAGCCGTTATTTGCATAG