Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2138029..2138666 Replicon chromosome
Accession NZ_CP053676
Organism MAG: Ferrovum myxofaciens isolate S2.4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HO274_RS10485 Protein ID WP_273119410.1
Coordinates 2138029..2138421 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID -
Locus tag HO274_RS10490 Protein ID WP_273119413.1
Coordinates 2138436..2138666 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO274_RS10460 (HO274_10415) 2133592..2134449 - 858 WP_273119402.1 hydrolase 1, exosortase A system-associated -
HO274_RS10465 (HO274_10420) 2134436..2135257 - 822 WP_273119403.1 hydrolase 2, exosortase A system-associated -
HO274_RS10470 (HO274_10425) 2135254..2135505 - 252 WP_031598496.1 phosphopantetheine-binding protein -
HO274_RS10475 (HO274_10430) 2135579..2136016 - 438 WP_062187558.1 hypothetical protein -
HO274_RS10480 (HO274_10435) 2136085..2137755 - 1671 WP_273119407.1 ATP-binding protein -
HO274_RS10485 (HO274_10440) 2138029..2138421 - 393 WP_273119410.1 type II toxin-antitoxin system VapC family toxin Toxin
HO274_RS10490 (HO274_10445) 2138436..2138666 - 231 WP_273119413.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HO274_RS10495 (HO274_10450) 2138663..2139259 - 597 WP_273119415.1 EAL domain-containing protein -
HO274_RS10500 (HO274_10455) 2139276..2140004 - 729 WP_273119417.1 PEP-CTERM sorting domain-containing protein -
HO274_RS10505 (HO274_10460) 2140188..2140589 - 402 WP_273119419.1 type II toxin-antitoxin system VapC family toxin -
HO274_RS10510 2140589..2140978 - 390 WP_273119423.1 type II toxin-antitoxin system VapB family antitoxin -
HO274_RS10515 (HO274_10470) 2141024..2141437 - 414 WP_273119428.1 putative toxin-antitoxin system toxin component, PIN family -
HO274_RS10520 (HO274_10475) 2141572..2142051 + 480 WP_273119431.1 hypothetical protein -
HO274_RS10525 (HO274_10480) 2142223..2142456 + 234 WP_273119435.1 type II toxin-antitoxin system RelE/ParE family toxin -
HO274_RS10530 (HO274_10485) 2142541..2142861 + 321 WP_273119438.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2106482..2343663 237181


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-121)

Antitoxin

SpoVT-AbrB domain

(7-42)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14582.60 Da        Isoelectric Point: 5.6023

>T157427 WP_273119410.1 NZ_CP053676:c2138421-2138029 [Ferrovum myxofaciens]
MLDTNICIYIAKHNPPIVKERFARHAASELAMSVITLGELRFGAEKSQSREQALTVISQLETMIQIAPLSEAVGEHYGQI
RATLQRCGQPIGNNDLWLAAHARAEGWILVTNNEREFDRVEGLQVENWSV

Download         Length: 393 bp

>T157427 NZ_CP069308:c842552-842052 [Glaesserella parasuis]
ATGAAGAGTAAGTTTATTGAAGAGCCTTTAACGAAGCATCATCAACGAGAAGCCTTTGATTGCGGAAATCTAGAGATGAA
CCGATTTTTTAAACAATACGCTCGGCAATCTCACGAAAAAGGGACATCAAAAACTTACATTAGCCGACACTTAGACAGTC
AACAGATTATCGGATTTTATACAATCACCTTAAGTGCATTAGACCAGCAACACTTACCCGAACTATGCAAAAAACGTTTT
GGCTACTACCCTATTCCGCTCTTTACATTAGCAAGACTTGCAGTGGATATTCGCTATCAAAAACAAGGCATTGGCGGAAT
GCTGTTAGTTAAAGCTCTCAAACGCTGTGCCATCGTTGCCGAACAAGTCGGGGGAATTGGGCTTCTCATTGAAGCAAAAG
ATGAAGACATTTCTCGTTGGTATCAATCTTATGGTGCTATTCCATTGGAAAATATGCCATTAACCTTAATTCTACTCTTT
GATACAATCAAAGGACTTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8841.04 Da        Isoelectric Point: 5.0916

>AT157427 WP_273119413.1 NZ_CP053676:c2138666-2138436 [Ferrovum myxofaciens]
MIYARIFKSGNSQAVRLPKEFRFDVAQVEIFRRGDEIVLREQATNALPLFDVLSSLPKDFMAHERDDAPPQERESF

Download         Length: 231 bp

>AT157427 NZ_CP069308:c842829-842542 [Glaesserella parasuis]
ATGCCACAAATTGCAAATGCCCTTAACGATAGAATGTCTATTCGCATTAGTACGGAAGACAAGCAGACTTTAATTAGAGC
CGTTGCACTCACCCATACGAATATTACAGAATTTGTATTACAACGCATTTTGCCTAGTGCCAGAGAAATTATTCAGCAGT
ATGATAATCGGCAATTTTCACCGCAAGATCTCTCGTTGATTATGGAATTGCTTGATAATCCGCCGAAAGCTAATACAAAA
CTACAACAAGCGGCGAAATTAGCAAAGGAAAGCTATCATGAAGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References