Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 998486..999030 Replicon chromosome
Accession NZ_CP053676
Organism MAG: Ferrovum myxofaciens isolate S2.4

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HO274_RS04835 Protein ID WP_031596839.1
Coordinates 998486..998812 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HO274_RS04840 Protein ID WP_273121846.1
Coordinates 998809..999030 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO274_RS04805 (HO274_04780) 993736..994377 + 642 WP_273121834.1 response regulator transcription factor -
HO274_RS04810 (HO274_04785) 994385..996193 - 1809 WP_273121835.1 DUF748 domain-containing protein -
HO274_RS04815 (HO274_04790) 996238..996639 - 402 WP_273121837.1 type II toxin-antitoxin system VapC family toxin -
HO274_RS04820 (HO274_04795) 996636..996866 - 231 WP_273121839.1 hypothetical protein -
HO274_RS04825 (HO274_04800) 996929..997405 - 477 WP_273121841.1 OsmC family protein -
HO274_RS04830 (HO274_04805) 997402..997836 - 435 WP_273121843.1 hypothetical protein -
HO274_RS04835 (HO274_04810) 998486..998812 - 327 WP_031596839.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HO274_RS04840 (HO274_04815) 998809..999030 - 222 WP_273121846.1 antitoxin MazE family protein Antitoxin
HO274_RS04845 (HO274_04820) 999199..999621 - 423 WP_031599221.1 type II toxin-antitoxin system VapC family toxin -
HO274_RS04850 (HO274_04825) 999618..999932 - 315 WP_031599223.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
HO274_RS04855 (HO274_04830) 1000236..1001786 - 1551 WP_273121848.1 transposase -
HO274_RS04860 (HO274_04835) 1002105..1004027 + 1923 WP_273121850.1 nucleoside-diphosphate sugar epimerase/dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 959620..1019081 59461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-105)

Antitoxin

Antitoxin MazE-like

(7-71)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11683.81 Da        Isoelectric Point: 9.2533

>T157425 WP_031596839.1 NZ_CP053676:c998812-998486 [Ferrovum myxofaciens]
MMRGDFVTIVMQGDFGKPRPALVIQADQFGEHATVTVLPMTSTLVAAPLLRTPIQPSAENGLNKPSQVMIDKAMTVKRDK
LGQAFGRIDGVVMTEVERCLAVFLGIAK

Download         Length: 327 bp

>T157425 NZ_CP069308:399376-399552 [Glaesserella parasuis]
ATGAAACAAAGTGAATTTTTAAGATGGCTAATTGCTCAAGGGGTAGTAAAGGAAGAAGGCTCAAAGCACATCAAACTTTA
TTACAACGGTAATCAATCAACAATGCCAAGACAACCTAGCAAGGAAATCAAAAACGGCACAATGAGAGCGATTAAAAAGC
AATTAGGTTTAAACTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8651.77 Da        Isoelectric Point: 6.2122

>AT157425 WP_273121846.1 NZ_CP053676:c999030-998809 [Ferrovum myxofaciens]
MATHVNTRVQRHRDTLRMAGLRPIQIWVPDTRRPDFAEECRRQSRLVAQTDMVDTNLQHFMDEALADMEGWTE

Download         Length: 222 bp

>AT157425 NZ_CP069308:399599-400012 [Glaesserella parasuis]
ATGCTGTATCCAGCACGATTCGAATTTGAAGATGGTAGTTATAATGTTTCATTCCGTGATATTCCTGAAGCGTTGACTTG
CGGTGATAACTACGAAGACGCTTTAGAGATGGCAAAAGATGCATTGCTTACCAGTATGGATTTTTATTTCGAAGATCATC
GCAAAGTACCGTTACCAAGCCCACCACAAGAAGGCGAAGTGCTGATCGAATTACCGACAAGTATTTTCGCCAAAGTGCTA
TTGCTAAATGAGATGGTCGATCAGAATATCTCCAATGTGGAATTAGCAAAACGAATTGCCGTAAAACCGCAAGAAGTACA
GCGTATTACTAATCTTGGGCATAGTACAAAAATCGATACTATTGCAAGAGCGATTAATGCACTCGACAAACAGTTTGAAT
TACGTGTTGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References