157423

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 624882..625580 Replicon chromosome
Accession NZ_CP053676
Organism MAG: Ferrovum myxofaciens isolate S2.4

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag HO274_RS03075 Protein ID WP_273121421.1
Coordinates 624882..625115 (-) Length 78 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag HO274_RS03080 Protein ID WP_273121424.1
Coordinates 625116..625580 (-) Length 155 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO274_RS03040 (HO274_03040) 620198..620527 - 330 WP_273121406.1 DUF2924 domain-containing protein -
HO274_RS03045 620557..620748 + 192 WP_273121174.1 hypothetical protein -
HO274_RS03050 (HO274_03050) 620842..621633 + 792 WP_273121409.1 hypothetical protein -
HO274_RS03055 (HO274_03055) 621626..622150 + 525 WP_273121411.1 hypothetical protein -
HO274_RS03060 (HO274_03060) 622200..622439 + 240 WP_273121414.1 hypothetical protein -
HO274_RS03065 622423..623664 + 1242 WP_273121417.1 hypothetical protein -
HO274_RS03070 623603..624454 + 852 WP_273121419.1 phage/plasmid primase, P4 family -
HO274_RS03075 (HO274_03070) 624882..625115 - 234 WP_273121421.1 hypothetical protein Toxin
HO274_RS03080 (HO274_03075) 625116..625580 - 465 WP_273121424.1 helix-turn-helix domain-containing protein Antitoxin
HO274_RS03085 (HO274_03080) 626312..626590 + 279 WP_273121427.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
HO274_RS03090 (HO274_03085) 626562..626891 + 330 WP_035416887.1 type II toxin-antitoxin system YafQ family toxin -
HO274_RS03095 (HO274_03090) 626857..627234 - 378 WP_273121429.1 HNH endonuclease -
HO274_RS03100 (HO274_03095) 627313..627468 + 156 WP_156472722.1 hypothetical protein -
HO274_RS03105 (HO274_03100) 627612..627923 - 312 WP_031597379.1 addiction module antidote protein -
HO274_RS03110 (HO274_03105) 627913..628245 - 333 WP_273121432.1 type II toxin-antitoxin system RelE/ParE family toxin -
HO274_RS03115 (HO274_03110) 628400..628687 - 288 WP_273121434.1 ATP-binding protein -
HO274_RS03120 628806..629846 + 1041 WP_273121435.1 transposase -
HO274_RS03125 (HO274_03115) 629771..630133 + 363 WP_273122262.1 transposase -
HO274_RS03130 (HO274_03120) 630228..630506 - 279 WP_273121437.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

SinI-like, DNA-binding domain

(83-130)


Sequences

Toxin        


Download         Length: 78 a.a.        Molecular weight: 9139.61 Da        Isoelectric Point: 9.0855

>T157423 WP_273121421.1 NZ_CP053676:c625115-624882 [Ferrovum myxofaciens]
MSSNFTVIYDACVLYPAPLRDFLMRLALTDLFRARWTDMIHDEWTRNVLKQRPDLKAKDLERTRSLMNAHVRDSLVT

Download         Length: 234 bp

>T157423 NZ_CP069306:1322933-1323193 [Rhodococcus aetherivorans]
ATGCGAACTATGAGCTACAGCGAATCGCGCGCCCGGTACGCCGAGGTCTTGGACTCTGTCGTCAACGACCGAGAGGAGAT
CGTCATTACCCGCTCGGGCCACGAGCCCGTTGTGATCGTCTCCCTGGCGGACTTCGAGTCGCTGCGGGAAACGGCTTACC
TGATGCGTTCACCGGCGAACGCTCGACGTCTGCTCGACGCGATGGAACGGCTCGAGGCAGGCGAGGGGCAAGTGCACGAA
CTGATCGAGGGTGACGACTGA

Antitoxin


Download         Length: 155 a.a.        Molecular weight: 17242.60 Da        Isoelectric Point: 5.6647

>AT157423 WP_273121424.1 NZ_CP053676:c625580-625116 [Ferrovum myxofaciens]
MTTLSPTHSLPTTEEVSIARESGRALSAYLQTRAETQQIEIVDDKGTAHPVRIPVSALRLLVNVLTEIGEGNAVSIIPIY
AELTTQDAADILNVSRPFFVQLLERGEIQFHKIGTHRRVRYRDVIEYKERIDAERGKALDALTEQAQALKMGYE

Download         Length: 465 bp

>AT157423 NZ_CP069306:1323196-1323456 [Rhodococcus aetherivorans]
GTGCGGCTGGTGTGGGACGTCAATGCCTGGGAGGACTACCTGTGGTGGCAGACCCAGGATCGGAAGGTATTGAGACGCAT
CAACGCATTGGTACAGGACATCCTGCGCAACGGTAACGAAGGAATCGGCAAGCCTGAGCCGTTGAAACATGATTTCGCAG
GCTATTGGTCCCGGCGCATTACGGATGAACATCGCCTGGTCTACAAGATCACCGACACAGAGGTCCGCATCGCTGCGTGC
CGCTATCACTACGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References