Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 573337..574882 Replicon chromosome
Accession NZ_CP053676
Organism MAG: Ferrovum myxofaciens isolate S2.4

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag HO274_RS02820 Protein ID WP_273121313.1
Coordinates 573337..574632 (-) Length 432 a.a.

Antitoxin (Protein)


Gene name HipB2 Uniprot ID -
Locus tag HO274_RS02825 Protein ID WP_273121315.1
Coordinates 574622..574882 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO274_RS02815 (HO274_02820) 568767..571547 - 2781 WP_273121310.1 AMP-binding protein -
HO274_RS02820 (HO274_02830) 573337..574632 - 1296 WP_273121313.1 type II toxin-antitoxin system HipA family toxin Toxin
HO274_RS02825 (HO274_02835) 574622..574882 - 261 WP_273121315.1 helix-turn-helix transcriptional regulator Antitoxin
HO274_RS02830 (HO274_02840) 575384..575623 + 240 WP_273121318.1 hypothetical protein -
HO274_RS02835 (HO274_02845) 575786..577627 + 1842 WP_273122252.1 GGDEF and EAL domain-containing protein -
HO274_RS02840 (HO274_02850) 577757..578209 - 453 WP_273121320.1 transposase -
HO274_RS02845 (HO274_02855) 578222..579196 - 975 WP_273121322.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(147-377)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-64)


Sequences

Toxin        


Download         Length: 432 a.a.        Molecular weight: 47455.40 Da        Isoelectric Point: 6.4394

>T157422 WP_273121313.1 NZ_CP053676:c574632-573337 [Ferrovum myxofaciens]
MAHELEVWLFADRAGTLALVAGRLTFCYDPNWLSRPQAAALSASLPLQAEPFDYHKTRPFFAGLLPEGQMRRLIAQQFQV
SNQNDFALLDHIGGECAGAVTFLEPGQALPASTQCEDIQWLSDEEVIAILDELPRRPMLAGKDGLRLSLAGAQDKLPVVF
DGARIGLPHNGTPSSHILKPPIHAVEDSVANEGFCLALADTLQLKPAKAKVHSIGTRSFLLVERYDRSLDKVGHRLRIHQ
EDFCQALGVVPEMKYQNEGGPDLAQCFDLVRRVSRPSAPQVLRLLDYVIFNALTGNHDAHAKNFSLLYLIEGPVLAPFYD
TLSTAVYPMLTPKMAMKIGSKYKFSETQARHWDQLAEGAGLAKALTKKRILELAKSLPPTARKIQSDPGHGFSGNAVVER
IIALIEQRCALTIRRLTDPAVDDEDDTEPSS

Download         Length: 1296 bp

>T157422 NZ_CP069304:273593-274018 [Shinella sp. PSBB067]
ATGATCCTCCTCGACACGAATGTCGTTTGCGAGGCGATGAAGCCCGAACCCGCCGCGGCGGTGATCGCCTGGCTCTACGG
CCAGGTCGCCGAAACGGCCTTTCTTTCCAGCGTCATCATCGCCGGATTGATGTCCGGCATCGGCGCCCTGCCTGATGGCC
GCCGCAAGCAGGGACCGGCCGAGGCGCTGGACGGCGTCACAGAGATATTCGAAGGCCGCATCCTGCCCTTCGACGTCGCC
GCGGCAAGGCGATACGCGGATCTTGCGGTTGAGGCCCGCGCGGCCAGCCGAGACTTCCCCACGCCGGACGGCTATATCGC
CGCCATCGCCGCCGCGCACGGCTTTGCCATCGCCACGCGCAGCAAAAGCGCGTTCGACGCGGCGGGCCTTGTCGTGATCG
ATCCCTGGGCCACACCGGTCGGTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 8955.25 Da        Isoelectric Point: 7.0104

>AT157422 WP_273121315.1 NZ_CP053676:c574882-574622 [Ferrovum myxofaciens]
MTTIRSPQQLGDALRAARKQLVLTQPQLALAAGVGVRFIVDLEAGKPTLRLENVLRVIDALGGEITIGGLPSGAAEDQRS
GNDHGA

Download         Length: 261 bp

>AT157422 NZ_CP069304:273342-273596 [Shinella sp. PSBB067]
ATGCCCGCCGTCACGATCGGAAATCTCTCCGCGGCGACGCACCGGGCGCTGAAGGTGCGCGCGGCCCATCATGGGCGCAG
CACGGAGGCCGAAATGCGCGAGATCCTCGAATCGGCGGCCCGTCCGCAGGCCCGGCTGCGGCCCGGCAGCGCGCTGGTCG
AGCGAAGCCGCCGCCTCGGCCTCACCAGCGAGGACGTCGCCGGCCGCGACGAGACGCTGGCCCGCGCGCCGGTCGAACCG
ATGGGCTTGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References