Detailed information of TA system TA157419

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapB(antitoxin)
• Location: 2329555..2329922
• Replicon: chromosome
• Accession: NZ_CP053675
• Organism: MAG: Ferrovum myxofaciens isolate MI1A

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HO273_RS11615
• Protein ID: WP_273180770.1
• Coordinates: 2329555..2329719 (-)
• Length: 55 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A859AAH2
• Locus tag: HO273_RS11620
• Protein ID: WP_031599546.1
• Coordinates: 2329716..2329922 (-)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HO273_RS11590 (HO273_11100)	2324747..2327617	+	2871	WP_273144395.1	UvrD-helicase domain-containing protein	-
HO273_RS11595 (HO273_11105)	2327698..2328006	+	309	WP_273144396.1	IS66 family insertion sequence element accessory protein TnpB	-
HO273_RS11600 (HO273_11110)	2328006..2328215	+	210	WP_197456580.1	IS66 family insertion sequence element accessory protein TnpB	-
HO273_RS11605 (HO273_11115)	2329017..2329211	-	195	WP_062188518.1	hypothetical protein	-
HO273_RS11610 (HO273_14005)	2329338..2329520	-	183	WP_273180767.1	hypothetical protein	-
HO273_RS11615 (HO273_14010)	2329555..2329719	-	165	WP_273180770.1	hypothetical protein	Toxin
HO273_RS11620 (HO273_11125)	2329716..2329922	-	207	WP_031599546.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
HO273_RS11625 (HO273_11130)	2330225..2330614	-	390	WP_031598816.1	nucleotidyltransferase domain-containing protein	-
HO273_RS11630 (HO273_11135)	2330713..2331132	-	420	WP_062188503.1	type II toxin-antitoxin system VapC family toxin	-
HO273_RS11635 (HO273_11140)	2331119..2331379	-	261	WP_031598819.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
HO273_RS11640 (HO273_11145)	2331605..2332777	-	1173	WP_062188502.1	glycosyltransferase family 4 protein	-
HO273_RS11645 (HO273_11150)	2332783..2333997	-	1215	WP_031598823.1	glycosyltransferase, exosortase A system-associated	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2292505..2496827	204322
	-	flank	IS/Tn	-	-	2328006..2328215	209

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-44)

Sequences

Toxin

Protein

• Length: 55 a.a.
• Molecular weight: 5768.61 Da
• Isoelectric Point: 4.1114

>T157419 WP_273180770.1 NZ_CP053675:c2329719-2329555 [Ferrovum myxofaciens]
MSVLIDTSVWIDHFRNGNDALIDLIGLDLALTHPMVILEIACGTPPSATHPDTG

Nucleotide

• Length: 165 bp

>T157419 NZ_CP069296:224737-225087 [Metabacillus sp. cB07]
TTGATTGTCAAACGCGGCGACGTTTATTTTGCTGATTTATCACCTGTTGTCGGCTCTGAGCAAGGCGGGGTCCGTCCGGT
ACTGATCATTCAGAATGATATCGGAAACAGGTTCAGTCCTACGGTCATCATAGCAGCCATCACTGCTCAAATTCAGAAAG
CGAAGCTTCCAACCCATGTGGAAATTGATTCAAAGCGATATGGATTTGAACGTGACTCTGTTATCCTGCTGGAACAGATC
CGAACAATTGATAAACAGAGATTGACTGATAAGATTACACACTTAGATGATGAAATGATGGATAAAGTGGACGAAGCTTT
GCAAATAAGCTTGGGACTCATTGATTTTTAA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7775.06 Da
• Isoelectric Point: 8.6365

>AT157419 WP_031599546.1 NZ_CP053675:c2329922-2329716 [Ferrovum myxofaciens]
MRTTVTIDDALYEKALEMADPNMDKSDIFREAIKTFVRVQAAKRLATLGGMIPKIQDVPRRREEPVVQ

Nucleotide

• Length: 207 bp

>AT157419 NZ_CP069296:224451-224732 [Metabacillus sp. cB07]
GTGTCTGAATCCAGCGCAACAACAGAAATCTTAATTCGACTGCCGCAAGCATTGGTCTCGGAGTTAGACGGTCTTGTGAA
ACAGGAAAATGGGAATCGGAGCGAGTTAATTTATCAAGCAACGAAAATGTATATCCGCGAACGCAAAAAGCGTCAGATTC
GCGAGTCTATGAGACGCGGTTACATGGAAATGGCCAAGATTAACTTAAACATTGCTTCCGAAGCATTTCAGGCTGAATCA
GAGGCTGACCACACCGTTGAACGCTTAGTAAGCGGGGGTTAA