Detailed information of TA system TA157418

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2318235..2319780
• Replicon: chromosome
• Accession: NZ_CP053675
• Organism: MAG: Ferrovum myxofaciens isolate MI1A

Toxin (Protein)

• Gene name: HipA1
• Uniprot ID: -
• Locus tag: HO273_RS11550
• Protein ID: WP_273144385.1
• Coordinates: 2318235..2319530 (-)
• Length: 432 a.a.

Antitoxin (Protein)

• Gene name: HipB2
• Uniprot ID: A0A8F3DWC8
• Locus tag: HO273_RS11555
• Protein ID: WP_031596370.1
• Coordinates: 2319520..2319780 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2292505..2496827	204322

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-63)

Sequences

Toxin

Protein

• Length: 432 a.a.
• Molecular weight: 47508.49 Da
• Isoelectric Point: 6.7319

>T157418 WP_273144385.1 NZ_CP053675:c2319530-2318235 [Ferrovum myxofaciens]
MAHELEVWLFADRAGTLTLVAGRLAFCYDPNWLSRPQAVALSVSLPLQAEPFDDHKTRPFFAGLLPEGQMRRLIAQQFQV
SNQNDFALLDHIGGECAGAVTFLEPGQALPASTQCEDIQWLSNEEVIAILDELPHRPMLAGKDGLRLSLAGAQDKLPVVF
DGARIGLPHNGTPSSHILKPPIHAVEDSVANEGFCLTLANTLQLKPAKAKVHSIGTRSFLLVERYDRSLDKVGHRRRIHQ
EDFCQALGVVPEIKYQNEGGPDLAQCFDLVRRVSRPSAPQVLRLLDYVIFNALTGNHDAHAKNFSLLYLIEGPVLAPFYD
TLSTAVYPMLTPKMAMKIGSKYKFSEIQARHWDQLAEGAGLAKALTKKRILELAKSLPPTARKIQSDPGHGFSGNAVVER
IIALIEQRCALTIRRLTDPAVDNEDDTEPSS

Nucleotide

• Length: 1296 bp

>T157418 NZ_CP069288:201000-201350 [Priestia megaterium]
TTGGTAGTCAAACGTGGCGACGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGAGGCGTTCGCCCTGT
ACTTGTCATTCAAAATGATATAGGCAATCGTTTTAGCCCAACTGTTATTGTAGCTGCGATCACTGCTCAAATTCAAAAGG
CAAAGTTACCTACGCATGTTGAAATTGATGCAAAGCGCTATGGATTTGAGCGAGATTCAGTTATTTTACTAGAACAAATT
CGTACTATTGATAAACAGAGGCTAACAGACAAGATTACCCATTTAGATGATGAAATGATGGACAGAGTGGATGAAGCCTT
GCAAATCAGTGTAGGACTTATCGACTTTTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9023.37 Da
• Isoelectric Point: 6.2463

>AT157418 WP_031596370.1 NZ_CP053675:c2319780-2319520 [Ferrovum myxofaciens]
MTTIRSPQQLGDALRAARKQLALTQPQLALAAGVGVRFIVDLEAGKPTLRLENVLRVIDALGGEIIISGLPSGVAEDQRS
GNDYGA

Nucleotide

• Length: 261 bp

>AT157418 NZ_CP069288:200714-200995 [Priestia megaterium]
GTGTCTGAAGCGAGCGCAACTACAGAAATCCTAGTAAGATTACCGAAAAATTTAGTATCGGAGCTCGATCTTATGGTTAA
ACAAGAAAATGGCAACCGAAGTGATTTTATTCACCAAGCAACAAAATTGTACCTTCGTGAGCGAAAAAAACGCCATATTC
GCGAATCAATGAGACGTGGATATATGGAGATGGCAAAGATAAACTTAAATATTGCTTCCGAGGCTTTTCTAGCAGAGTAT
GAAGCTGATCATACTGTGGATCGTTTAGTAAGCGGGGGGTAA