Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2318235..2319780 Replicon chromosome
Accession NZ_CP053675
Organism MAG: Ferrovum myxofaciens isolate MI1A

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag HO273_RS11550 Protein ID WP_273144385.1
Coordinates 2318235..2319530 (-) Length 432 a.a.

Antitoxin (Protein)


Gene name HipB2 Uniprot ID A0A8F3DWC8
Locus tag HO273_RS11555 Protein ID WP_031596370.1
Coordinates 2319520..2319780 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO273_RS11510 2314252..2314527 + 276 WP_273145488.1 hypothetical protein -
HO273_RS11515 (HO273_11020) 2314641..2314943 - 303 WP_273202645.1 hypothetical protein -
HO273_RS11520 (HO273_11025) 2315351..2315683 + 333 WP_031598571.1 helix-turn-helix domain-containing protein -
HO273_RS11525 (HO273_11030) 2315673..2316923 + 1251 WP_273144380.1 HipA domain-containing protein -
HO273_RS11530 (HO273_11035) 2317103..2317279 + 177 WP_273119555.1 type II toxin-antitoxin system HicA family toxin -
HO273_RS11535 (HO273_11040) 2317293..2317712 + 420 WP_273144382.1 type II toxin-antitoxin system HicB family antitoxin -
HO273_RS11540 (HO273_11045) 2317831..2318025 - 195 WP_062188518.1 hypothetical protein -
HO273_RS11545 (HO273_14000) 2318024..2318170 + 147 WP_197456531.1 hypothetical protein -
HO273_RS11550 (HO273_11055) 2318235..2319530 - 1296 WP_273144385.1 type II toxin-antitoxin system HipA family toxin Toxin
HO273_RS11555 (HO273_11060) 2319520..2319780 - 261 WP_031596370.1 helix-turn-helix transcriptional regulator Antitoxin
HO273_RS11560 (HO273_11070) 2319910..2320611 - 702 WP_062188520.1 UPF0149 family protein -
HO273_RS11565 (HO273_11075) 2320708..2321925 - 1218 WP_273144388.1 transposase -
HO273_RS11570 (HO273_11080) 2321946..2322359 + 414 WP_082783440.1 IS200/IS605 family transposase -
HO273_RS11575 (HO273_11085) 2322369..2322512 + 144 WP_273144389.1 hypothetical protein -
HO273_RS11580 (HO273_11090) 2322787..2323194 + 408 WP_273144391.1 IS200/IS605 family transposase -
HO273_RS11585 (HO273_11095) 2323191..2324717 + 1527 WP_273144393.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2292505..2496827 204322


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-63)


Sequences

Toxin        


Download         Length: 432 a.a.        Molecular weight: 47508.49 Da        Isoelectric Point: 6.7319

>T157418 WP_273144385.1 NZ_CP053675:c2319530-2318235 [Ferrovum myxofaciens]
MAHELEVWLFADRAGTLTLVAGRLAFCYDPNWLSRPQAVALSVSLPLQAEPFDDHKTRPFFAGLLPEGQMRRLIAQQFQV
SNQNDFALLDHIGGECAGAVTFLEPGQALPASTQCEDIQWLSNEEVIAILDELPHRPMLAGKDGLRLSLAGAQDKLPVVF
DGARIGLPHNGTPSSHILKPPIHAVEDSVANEGFCLTLANTLQLKPAKAKVHSIGTRSFLLVERYDRSLDKVGHRRRIHQ
EDFCQALGVVPEIKYQNEGGPDLAQCFDLVRRVSRPSAPQVLRLLDYVIFNALTGNHDAHAKNFSLLYLIEGPVLAPFYD
TLSTAVYPMLTPKMAMKIGSKYKFSEIQARHWDQLAEGAGLAKALTKKRILELAKSLPPTARKIQSDPGHGFSGNAVVER
IIALIEQRCALTIRRLTDPAVDNEDDTEPSS

Download         Length: 1296 bp

>T157418 NZ_CP069288:201000-201350 [Priestia megaterium]
TTGGTAGTCAAACGTGGCGACGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGAGGCGTTCGCCCTGT
ACTTGTCATTCAAAATGATATAGGCAATCGTTTTAGCCCAACTGTTATTGTAGCTGCGATCACTGCTCAAATTCAAAAGG
CAAAGTTACCTACGCATGTTGAAATTGATGCAAAGCGCTATGGATTTGAGCGAGATTCAGTTATTTTACTAGAACAAATT
CGTACTATTGATAAACAGAGGCTAACAGACAAGATTACCCATTTAGATGATGAAATGATGGACAGAGTGGATGAAGCCTT
GCAAATCAGTGTAGGACTTATCGACTTTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9023.37 Da        Isoelectric Point: 6.2463

>AT157418 WP_031596370.1 NZ_CP053675:c2319780-2319520 [Ferrovum myxofaciens]
MTTIRSPQQLGDALRAARKQLALTQPQLALAAGVGVRFIVDLEAGKPTLRLENVLRVIDALGGEIIISGLPSGVAEDQRS
GNDYGA

Download         Length: 261 bp

>AT157418 NZ_CP069288:200714-200995 [Priestia megaterium]
GTGTCTGAAGCGAGCGCAACTACAGAAATCCTAGTAAGATTACCGAAAAATTTAGTATCGGAGCTCGATCTTATGGTTAA
ACAAGAAAATGGCAACCGAAGTGATTTTATTCACCAAGCAACAAAATTGTACCTTCGTGAGCGAAAAAAACGCCATATTC
GCGAATCAATGAGACGTGGATATATGGAGATGGCAAAGATAAACTTAAATATTGCTTCCGAGGCTTTTCTAGCAGAGTAT
GAAGCTGATCATACTGTGGATCGTTTAGTAAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References