Detailed information of TA system TA157417

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 2317103..2317712
• Replicon: chromosome
• Accession: NZ_CP053675
• Organism: MAG: Ferrovum myxofaciens isolate MI1A

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HO273_RS11530
• Protein ID: WP_273119555.1
• Coordinates: 2317103..2317279 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HO273_RS11535
• Protein ID: WP_273144382.1
• Coordinates: 2317293..2317712 (+)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HO273_RS11505 (HO273_11015)	2313119..2314018	-	900	WP_273145430.1	transposase	-
HO273_RS11510	2314252..2314527	+	276	WP_273145488.1	hypothetical protein	-
HO273_RS11515 (HO273_11020)	2314641..2314943	-	303	WP_273202645.1	hypothetical protein	-
HO273_RS11520 (HO273_11025)	2315351..2315683	+	333	WP_031598571.1	helix-turn-helix domain-containing protein	-
HO273_RS11525 (HO273_11030)	2315673..2316923	+	1251	WP_273144380.1	HipA domain-containing protein	-
HO273_RS11530 (HO273_11035)	2317103..2317279	+	177	WP_273119555.1	type II toxin-antitoxin system HicA family toxin	Toxin
HO273_RS11535 (HO273_11040)	2317293..2317712	+	420	WP_273144382.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HO273_RS11540 (HO273_11045)	2317831..2318025	-	195	WP_062188518.1	hypothetical protein	-
HO273_RS11545 (HO273_14000)	2318024..2318170	+	147	WP_197456531.1	hypothetical protein	-
HO273_RS11550 (HO273_11055)	2318235..2319530	-	1296	WP_273144385.1	type II toxin-antitoxin system HipA family toxin	-
HO273_RS11555 (HO273_11060)	2319520..2319780	-	261	WP_031596370.1	helix-turn-helix transcriptional regulator	-
HO273_RS11560 (HO273_11070)	2319910..2320611	-	702	WP_062188520.1	UPF0149 family protein	-
HO273_RS11565 (HO273_11075)	2320708..2321925	-	1218	WP_273144388.1	transposase	-
HO273_RS11570 (HO273_11080)	2321946..2322359	+	414	WP_082783440.1	IS200/IS605 family transposase	-
HO273_RS11575 (HO273_11085)	2322369..2322512	+	144	WP_273144389.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2292505..2496827	204322

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-58)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6335.41 Da
• Isoelectric Point: 11.0145

>T157417 WP_273119555.1 NZ_CP053675:2317103-2317279 [Ferrovum myxofaciens]
MNSKQMKKWLEQQGATFQPGKGSHLKVFLNGKQSSLPMHGTAELGKGLEAAIKRQLGL

Nucleotide

• Length: 177 bp

>T157417 NZ_CP069278:504486-504770 [Bifidobacterium longum]
ATGAGCACCGAATTCACCGACTACGACACCAGCGAATACCTCGAAAACGAACAGGACATCATCGCCTACCTCAACGCCAT
AGCCGAATACGACGACCCCGCACTCATGCAGGCCGCGCTCGGCAACGTCGCCAAGGCCCGGGGCATGACCCAGATCGCCA
AGGACGCGGGCGTGGGGCGCGAAAGCCTCTACAAGAGCCTCAGCAAGGACGGCAACCCCAGCTTCCAAACCATCGCCAAG
GTAATCCACGCCCTCGGCGGACGCCTCACCATCCAAGCCGCCTGA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15177.39 Da
• Isoelectric Point: 4.7118

>AT157417 WP_273144382.1 NZ_CP053675:2317293-2317712 [Ferrovum myxofaciens]
MMFDYPVTLTPDDGTMLVTFADVPEAITFGADEDEALLNAIDALETGLSFYVDARKSLPVASQPAAGQKTVRPSALECAK
LGIYQAMTDQGIKKAELARRLGWHMPQVDRLFDLRHASKLDQIEAAANVLGKHVYVQIA

Nucleotide

• Length: 420 bp

>AT157417 NZ_CP069278:504181-504489 [Bifidobacterium longum]
ATGGAAATCAAGCAATCCGCCGAATACCGCAAGTGGTTCAAGAAACTCAGGGACCACAAAGCGAAGGCCGCCATCCAAGC
CCGGCTCGATGTCTGCAAGCTCGCAGGCAGGCCATTCGGCGACATCAAACCCGTGGGAGGCCCGGTCAGCGAGATGCGGT
TCCACACCGGGGCCGGATACCGCGTCTACTTCGCCATGCAGGGCAACGTGCTCATGCTGCTGCTCGCAGGCGGCGACAAA
AGCACCCAGCAGACCGACATCAGACAAGCCCACGACATCCTCAACGACTACAAGGAACAACGACAATGA