Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2198737..2199281 Replicon chromosome
Accession NZ_CP053675
Organism MAG: Ferrovum myxofaciens isolate MI1A

Toxin (Protein)


Gene name relE Uniprot ID A0A859AA89
Locus tag HO273_RS10890 Protein ID WP_031596929.1
Coordinates 2198737..2199012 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8F3E316
Locus tag HO273_RS10895 Protein ID WP_031596931.1
Coordinates 2199012..2199281 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO273_RS10860 (HO273_10375) 2193845..2195038 - 1194 WP_051862536.1 outer membrane protein assembly factor BamC -
HO273_RS10865 (HO273_10380) 2195100..2195993 - 894 WP_227509491.1 4-hydroxy-tetrahydrodipicolinate synthase -
HO273_RS10870 (HO273_10385) 2196138..2197052 + 915 WP_031598116.1 dTDP-4-dehydrorhamnose reductase -
HO273_RS10875 (HO273_10390) 2197049..2197606 + 558 WP_031598117.1 dTDP-4-dehydrorhamnose 3,5-epimerase -
HO273_RS10880 (HO273_10395) 2197603..2198475 + 873 WP_062188209.1 hypothetical protein -
HO273_RS10890 (HO273_10405) 2198737..2199012 - 276 WP_031596929.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HO273_RS10895 (HO273_10410) 2199012..2199281 - 270 WP_031596931.1 ribbon-helix-helix protein, CopG family Antitoxin
HO273_RS10900 (HO273_10415) 2199581..2199910 - 330 WP_031596933.1 hypothetical protein -
HO273_RS10905 (HO273_10420) 2199940..2201910 - 1971 WP_273144246.1 histidine kinase -
HO273_RS10915 (HO273_10430) 2202083..2203645 + 1563 WP_031595994.1 murein biosynthesis integral membrane protein MurJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10692.45 Da        Isoelectric Point: 9.8610

>T157416 WP_031596929.1 NZ_CP053675:c2199012-2198737 [Ferrovum myxofaciens]
MELKWTSKGLSDLARLYDFLVPVNKSAATRVVQALAAAPASLLVNPRIGEKLEEFEPREVRRILVGKYEMRYEIRESTIY
MLRLWHTREDR

Download         Length: 276 bp

>T157416 NZ_CP069278:504181-504489 [Bifidobacterium longum]
ATGGAAATCAAGCAATCCGCCGAATACCGCAAGTGGTTCAAGAAACTCAGGGACCACAAAGCGAAGGCCGCCATCCAAGC
CCGGCTCGATGTCTGCAAGCTCGCAGGCAGGCCATTCGGCGACATCAAACCCGTGGGAGGCCCGGTCAGCGAGATGCGGT
TCCACACCGGGGCCGGATACCGCGTCTACTTCGCCATGCAGGGCAACGTGCTCATGCTGCTGCTCGCAGGCGGCGACAAA
AGCACCCAGCAGACCGACATCAGACAAGCCCACGACATCCTCAACGACTACAAGGAACAACGACAATGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9916.32 Da        Isoelectric Point: 6.4818

>AT157416 WP_031596931.1 NZ_CP053675:c2199281-2199012 [Ferrovum myxofaciens]
MAHTDTKVLTAHVPLLLAEKVDRLATRLERSRGWIVKQALAAWIDMEEERTRLTHEGLADVDAGRVIDHQAVEAWANSLS
TAQPLPAPR

Download         Length: 270 bp

>AT157416 NZ_CP069278:504486-504770 [Bifidobacterium longum]
ATGAGCACCGAATTCACCGACTACGACACCAGCGAATACCTCGAAAACGAACAGGACATCATCGCCTACCTCAACGCCAT
AGCCGAATACGACGACCCCGCACTCATGCAGGCCGCGCTCGGCAACGTCGCCAAGGCCCGGGGCATGACCCAGATCGCCA
AGGACGCGGGCGTGGGGCGCGAAAGCCTCTACAAGAGCCTCAGCAAGGACGGCAACCCCAGCTTCCAAACCATCGCCAAG
GTAATCCACGCCCTCGGCGGACGCCTCACCATCCAAGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References