Detailed information of TA system TA157415

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1282833..1283608
• Replicon: chromosome
• Accession: NZ_CP053675
• Organism: MAG: Ferrovum myxofaciens isolate MI1A

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: A0A859A802
• Locus tag: HO273_RS06270
• Protein ID: WP_031596033.1
• Coordinates: 1282833..1283327 (-)
• Length: 165 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: A0A859AAZ0
• Locus tag: HO273_RS06275
• Protein ID: WP_031596032.1
• Coordinates: 1283324..1283608 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HO273_RS06255 (HO273_05785)	1278643..1281696	-	3054	WP_273146015.1	PAS domain S-box protein	-
HO273_RS06260 (HO273_05790)	1281895..1282146	+	252	WP_031596035.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
HO273_RS06265 (HO273_05795)	1282143..1282529	+	387	WP_031596034.1	type II toxin-antitoxin system VapC family toxin	-
HO273_RS06270 (HO273_05800)	1282833..1283327	-	495	WP_031596033.1	GNAT family N-acetyltransferase	Toxin
HO273_RS06275 (HO273_05805)	1283324..1283608	-	285	WP_031596032.1	DUF1778 domain-containing protein	Antitoxin
HO273_RS06280 (HO273_13930)	1283883..1284098	-	216	WP_273146017.1	hypothetical protein	-
HO273_RS06285 (HO273_05810)	1284932..1285804	+	873	WP_273121346.1	hypothetical protein	-
HO273_RS06290 (HO273_05815)	1285967..1287001	+	1035	WP_273202597.1	GTP 3',8-cyclase MoaA	-
HO273_RS06295 (HO273_05820)	1287041..1287580	+	540	WP_273121353.1	molybdopterin adenylyltransferase	-
HO273_RS06300 (HO273_05825)	1287577..1288068	+	492	WP_273146023.1	molybdopterin-guanine dinucleotide biosynthesis protein B	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (42-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (4-93)

Sequences

Toxin

Protein

• Length: 165 a.a.
• Molecular weight: 18208.89 Da
• Isoelectric Point: 8.5067

>T157415 WP_031596033.1 NZ_CP053675:c1283327-1282833 [Ferrovum myxofaciens]
MSLSAPQSLDANHRLEEFDCGKPALTDWLLRHARQAQGSGSAKTFVACDGSRVAGYFSLTVGQIDTLEAPERIRRGMGQY
PIPLVILARLAVDLDYQKQGLGFSLLQDAIRRTVAIAEHAGIRALLTHPIDAEAETFYRRFGFASTPVREQQLILLLKDA
RRFV

Nucleotide

• Length: 495 bp

>T157415 NZ_CP069278:c403391-402900 [Bifidobacterium longum]
ATGAGGCAGTCAAAGCAGGTGTCGATCTTGTGCGACACCAATATCCTTATTTATTACATGCTCTGTACGCCTCGGTTCAT
CAAGGATGTCATGAAACTGTTCGAGCGATGCGTCGAGCGGGAGGTAAAGCTGTCCTGTGCGTCACTGTCGCTGAAGGACG
TGTTCTACATCACCCCGGAACGATTCAAAGAACGATTCATGAATGACGAATCCATGGTCGTTGCGACCACCGCCAAGCTG
ATATTGCCGGAGGTGGCATGGTCGGGAATCAGCAAACTCAAGGAGCTCATGACAATCGTGCCGATTGGCGCGGAGGAATG
TGAATTGGCGCAGTCGTTGCGGCACGCGCATAACGATTTCGAGGATGACCTTATTATCGCCGCCGCACAACAATCCGGGG
CCACCTATGTGGTGACGTATGACAAAAAACTAGCCAAGCATTTTCCCGAATATTGCAAAACGCCGGCTGAAATCGTGGCG
GCGCTGGCATAG

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10516.92 Da
• Isoelectric Point: 6.4651

>AT157415 WP_031596032.1 NZ_CP053675:c1283608-1283324 [Ferrovum myxofaciens]
MTATTTARSARLGLRATPEQETVLRRAAEVAHKSLTDFILDAAYQAAEHTLLDQRLFMVSGSQYQALLEMLDRPESDNPG
LANLFSRRPVWAEK

Nucleotide

• Length: 285 bp

>AT157415 NZ_CP069278:c403780-403388 [Bifidobacterium longum]
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCGT
ATCGGTGAGTGACGTAATCCGGTCGCTGTGGTTGTACATCGCCGACCGCAAGGAAGTGCCGGCATTGGAAACGACCGCCG
AAGAGCAAGCCCGCGAGGAGGAAAAGCAGCGCAAGCTGAAACTGATTCGAGAAGGTGCCGGATACGTACACAAGGAACTG
GTCAAGGCCGGACTGATCTCAGAAGACACCGACCTCATGGAAGGCCTTACCTACAAGCAGTTCCGCGATGAGATAGCTGA
CGAACGGCTGAAGGAATACAGGCATCAGTCGGACTATGCGCGTTATTTGGAGAAGGAGCGGAGTCTGTCATGA