Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4734780..4735296 Replicon chromosome
Accession NZ_CP053666
Organism Klebsiella pneumoniae strain kpn-241

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag HPK15_RS23120 Protein ID WP_004178374.1
Coordinates 4734780..4735064 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HPK15_RS23125 Protein ID WP_002886901.1
Coordinates 4735054..4735296 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPK15_RS23095 (4730264) 4730264..4730527 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
HPK15_RS23100 (4730657) 4730657..4730830 + 174 WP_019725541.1 hypothetical protein -
HPK15_RS23105 (4730833) 4730833..4731576 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HPK15_RS23110 (4731933) 4731933..4734071 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HPK15_RS23115 (4734312) 4734312..4734776 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HPK15_RS23120 (4734780) 4734780..4735064 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPK15_RS23125 (4735054) 4735054..4735296 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HPK15_RS23130 (4735374) 4735374..4737284 - 1911 WP_031593171.1 PRD domain-containing protein -
HPK15_RS23135 (4737307) 4737307..4738461 - 1155 WP_002886900.1 lactonase family protein -
HPK15_RS23140 (4738528) 4738528..4739268 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T157407 WP_004178374.1 NZ_CP053666:c4735064-4734780 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T157407 NZ_CP069219:929734-930096 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT157407 WP_002886901.1 NZ_CP053666:c4735296-4735054 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT157407 NZ_CP069219:929567-929737 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTTCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References